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Padres vs Giants Prediction, Trends, Starting Pitchers and MLB Betting Odds

The finale of a three-game set between two NL West Division rivals is scheduled for Wednesday afternoon. After splitting the first two contests of the series, the San Diego Padres and San Francisco Giants will duke it out in a rubber game matchup today. Yesterday saw the Giants roll to a 13-2 victory and snap a four-game Padres winning streak in the process. MLB betting odds have installed the home team as a slight favorite for today’s Padres vs Giants prediction.

This Padres vs Giants MLB betting preview includes key game info, projected starting pitchers, betting odds, trends and a prediction for Wednesday afternoon’s matchup. But first, let’s take a look at this BetMGM promo that’s giving away free money!

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Padres vs Giants Prediction and MLB Betting Preview

MLB Regular Season Game
San Diego Padres (4-2, 4-2 Away) vs. San Francisco Giants (3-2, 3-2 Home)
Date: Wednesday, Apr. 13, 2022
Start Time: 3:45 p.m. EST
Venue: Oracle Park — San Francisco, CA
Coverage: MLB Network

Padres vs Giants Starting Pitchers

Away Team: Sean Manaea (1-0, 0.00 ERA)
Home Team: Logan Webb (0-0, 1.50 ERA)

San Diego Padres Preview

Yesterday’s lopsided defeat marked the first loss for the Padres since Opening Day. San Diego dominated the remainder of a season-opening four-game series at Arizona before taking the opener from the Giants on Monday night as well. After generating 10 hits as a team in the series opener, the Padres were held to half of that last night. Yu Darvish got shelled early on and the Padres never had a chance. They faced a 10-1 deficit after just two innings of play.

Preseason trade acquisition Sean Manaea will aim to get San Diego back on track in today’s MLB betting matchup. The Padres acquired Manaea less than two weeks before the start of the season in a move that bolstered a rotation that was already teeming with potential. The 30-year-old southpaw was brilliant in his San Diego debut. Manaea hurled seven shutout innings against the Diamondbacks and didn’t even allow a hit. Of course, that performance did come against arguably the worst lineup in all of baseball.

San Francisco Giants Preview

After dropping Monday’s game in the later innings, the Giants managed to rebound in a big way last night. Although MLB betting odds initially selected the Padres as the favorite, the market moved in San Francisco’s favor prior to the first pitch. Needless to say, the move proved dead-on accurate. Alex Cobb fanned ten over five innings and Wilmer Flores accounted for three of the team’s 15 hits (including a homer) as the Giants jumped out to an early lead and never looked back.

The Giants will turn to 25-year-old staff ace Logan Webb as their starting pitcher for today’s MLB betting contest. This will be Webb’s second start of the season. Although San Fran did win his Opening Day outing, Webb was a nonfactor in the decision. One could argue that he got robbed of a win as his one run allowed over six innings of work certainly counts as a quality start. Webb did suffer a minor ankle sprain covering first base in Friday’s game, but all signs indicate that he will be ready to roll today.

Logan Webb Padres vs Giants prediction MLB betting odds trends starting pitchers
Credit: Jeff Chiu/Associated Press

Padres vs Giants MLB Betting Odds

MLB betting odds for Padres vs Giants are taken from BetUS Sportsbook.

Moneyline: SD: (+118) | SF: (-128)
Run Line: SD: +1.5 (-190) | SF: -1.5 (+160)
Total: 7 — Over: (-120) | Under: (+100)
Public Betting Percentages via Action Network: SD: (49%) | SF: (51%)

  • Padres are just 1-6 straight up in their last seven games when their opponent scores five runs or more in their previous game.
  • The total has gone UNDER in each of the Padres’ last four games following a loss.
  • Giants are a perfect 11-0 in Logan Webb’s last 11 starts after allowing two runs or less in their previous game.
  • The OVER is 13-4 in the last 17 Padres vs Giants head-to-head matchups.
  • In the last 17 Padres vs Giants head-to-head matchups played in San Francisco, the OVER has gone 11-5-1.

Padres vs Giants Stats

  • San Diego is averaging 4.33 runs per game (RPG) this season (No. 15 in the MLB).
  • San Diego is surrendering 4.33 RPG this season (No. 18 in the MLB).
  • San Francisco is averaging 5.00 RPG this season (T-No. 8 in the MLB).
  • San Francisco is surrendering 3.00 RPG this season (No. 6 in the MLB).

Padres vs Giants Weather Report

According to

Status: Partly Cloudy
Temperature: 50℉
Humidity: 70%
Precipitation: 0%
Wind: 10 MPH (blowing out)

Padres vs Giants Prediction | MLB Betting Picks

The low MLB betting total of seven runs is very telling when it comes to this matchup. Sure, the odds are juiced to the over, but the fact that oddsmakers are holding firm at an even seven runs is a testament to the quality pitching matchup. Both Sean Manaea and Logan Webb have what it takes to carry the baton into deep waters for their respective ballclub. The fact that neither the Padres nor the Giants possess a mighty offense only furthers the expectation that a pitching duel could transpire.

Despite his sprained ankle, Webb is clearly the pitcher worth backing. This is pretty much the case every time he takes the mound for the Giants until we are proven otherwise. Among the MLB betting options at BetUS Sportsbook is a “Race to Four Runs” prop. While both teams are listed at plus-money odds, the Padres may be hard-pressed just to score four runs total in this matchup. After the Giants’ bats exploded yesterday, they seem like a good pick to win this race at +150 odds.

Padres vs Giants Prediction: Giants First to Score Four Runs (+150 at BetUS Sportsbook)

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