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Michigan State vs USC Prediction and NCAA Tournament March Madness Expert Picks

In a First Round NCAA Tournament game, the (7) Michigan State Spartans will face off with the (10) USC Trojans in the East Region. Let’s take a look at the top college basketball betting odds, March Madness expert picks, betting trends and KenPom Rankings, then give our Michigan State vs USC prediction. 

Michigan State vs USC Prediction and March Madness Expert Picks

2023 NCAA Tournament
No. 7 Michigan State Spartans (19-12) vs. No. 10 USC Trojans (22-10)
Date: Friday, March 17, 2022
Time: 12:15 AM EST
Venue: Nationwide Arena — Columbus, OH
Coverage: CBS

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Michigan State vs USC March Madness Betting Odds

All college basketball betting odds for Michigan State vs USC can be found at BetUS Sportsbook.

Moneyline: MSU: (-132) | USC: (+110)
Point Spread: MSU: -2 (-112) | USC: +2 (-107)
Total: 137.5 — Over: (-112) | Under: (-110)

KenPom Rankings | Bracketology

KenPom Rankings are from

Michigan State32113.496.764.9

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  • Michigan State is 15-16 against the spread (ATS) this season.
  • USC is 17-15 ATS this season.
  • The OVER is 11-8 in USC’s last 19 games.
  • The OVER is 17-15 for USC this season.
  • The OVER is 16-15 for Michigan State this season.

Michigan State vs USC Prediction | March Madness Expert Picks

Michigan State has had a tough run in Big Ten play this year. Although they finished fourth in the Big Ten, only two of their eight conference losses were to a ranked team (Purdue). The Spartans have a solid defense that only allows 67 points per game, but they aren’t very dynamic on offense. Michigan State averages just over 70 points per game which is 226th in the nation.

USC has been virtually the exact same team as Michigan State this year. They average just over 72 points per game and also give up 67 per game. While USC did finish with just six losses, they have had the benefit of playing in a much easier Pac-12 conference.

USC has lost two of three with their one win coming in a slim 68-65 victory over an Arizona State team that would come back and beat them in the Pac-12 tournament. Michigan State suffered the same fate against Ohio State who took them down by 10 after the Spartans beat them to close the regular season.

This game will be incredibly tight and it’ll likely come down to which defense will make more mistakes. Neither offense is good enough to take over the game and neither team sports a player that can be relied on to dominate consistently. As a result, pick USC to cover the spread, even if they’re only given two points.

Our college basketball betting Michigan State vs USC prediction tonight will be USC covers the spread at BetUS

For what it’s worth, the ESPN Matchup Predictor gives Michigan State a 59.6% chance to win

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