In the second game of a three-game series in the AL Central, the Cleveland Guardians are taking on the Minnesota Twins. Yesterday, it took 11 innings for the Guardians to beat the Twins, 6-5. The MLB oddsmakers’ Guardians vs Twins prediction for today sides with the home team.

Let’s take a closer look at this MLB game today in Minnesota, looking at the top MLB betting odds, trends and starting pitchers today. But first, let’s take a look at this special welcome offer from BetOnline Sportsbook.

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Guardians vs Twins Prediction and MLB Betting Preview

MLB Regular Season Game
Cleveland Guardians (35-28, 19-18 Away) vs. Minnesota Twins (38-31, 20-15 Home)
Date: Wednesday, June 22, 2022
Start Time: 7:40 p.m. EST
Venue: Target Field — Minneapolis, MN

Credit: Stacy Bengs/AP Photo

Guardians vs Twins Starting Pitchers

Guardians: Triston McKenzie (4-5 Record, 2.96 ERA)
Twins: Sonny Gray (3-1 Record, 2.09 ERA)

Guardians vs Twins MLB Betting Odds

MLB betting odds for Guardians vs Twins are taken from BetOnline Sportsbook.

Moneyline: CLE: (+136) | MIN: (-147)
Run Line: CLE: +1.5 (-159) | MIN: -1.5 (+139)
Total: 8.5 — Over: (-115) | Under: (-105)
Public Betting Percentages via Action Network: CLE: (67%) | MIN: (33%)

  • Yesterday, the Guardians defeated the Twins, 6-5 (F/11).
  • The Guardians are 7-1 straight up in their last eight games.
  • The OVER is 4-1 in Cleveland’s last five games against the American League.
  • The Guardians 4-1 straight up in their last five road games.
  • The OVER is 4-2 in the last six Guardians vs Twins matchups.
  • The Twins are 13-6 in their last 19 home games against the Guardians.
  • The OVER is 8-2 in Minnesota’s last eight home games.

Guardians vs Twins Stats

  • Cleveland is averaging 4.59 runs per game (RPG) this season (No. 12 in the MLB).
  • Cleveland is surrendering 4.02 RPG this season (No. 8 in the MLB).
  • Minnesota is averaging 4.42 RPG this season (No. 14 in the MLB).
  • Minnesota is surrendering 4.07 RPG this season (No. 10 in the MLB).

Guardians vs Twins Prediction | MLB Betting Picks

This Guardians vs Twins prediction is made through the ESPN Matchup Predictor. According to the tool, the Minnesota Twins have a 57.9% chance to win today.


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I am a simple Wisconsin man: I love beer and sports. I decided to create FlurrySports because I was sick of the politics and non-stories that the fat cat corporations put out. When you see football articles from me, just know that I combine my knowledge from playing, coaching, athletic training, and sports management/economic courses to give you a unique, but I feel well-rounded point of view. I am always down to talk about anything, so follow me on Twitter @FantasyFlurry if you decide you want more of me!

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