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Duke vs Michigan State Prediction, Bracketology and Pick for College Basketball NCAA Tournament

In a Round of 32 NCAA Tournament game, the (2) Duke Blue Devils will face off with the (7) Michigan State Spartans in the West Region. Let’s take a look at the top college basketball betting odds, picks, bracketology, betting trends and KenPom Rankings, then give our Duke vs Michigan State prediction for the game today. 

Duke vs Michigan State | NCAA Tournament Bracketology

2022 NCAA Tournament
No. 2 Duke Blue Devils (29-6) vs. No. 7 Michigan State Spartans (23-12)
Date: Sunday, March 20, 2022
Time: 5:15 PM EST
Venue: Bon Secours Wellness Arena — Greenville, SC
Coverage: CBS

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Duke vs Michigan State College Basketball Betting Picks and Odds

All college basketball betting odds for Duke vs Michigan State can be found at BetUS Sportsbook.

Moneyline: DUKE: (-270) | MSU: (+230)
Point Spread: DUKE: -6.5 (-110) | MSU: +6.5 (-110)
Total: 144.5 — Over: (-110) | Under: (-110)

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Duke vs michigan state Prediction, Bracketology and Pick for College Basketball NCAA Tournament
Credit: Rob Kinnan/USA TODAY Sports

KenPom Rankings | Bracketology

KenPom Rankings are from

Michigan State40111.396.467.5
  • Duke is 0-5 against the spread (ATS) in its last five games.
  • The OVER is 6-1 in Duke’s last seven games.
  • Duke is 15-3 straight up in its last 18 games.
  • Michigan State is 5-0 ATS in its last five games.
  • The OVER is 6-1 in Michigan State’s last seven games.
  • Coach K leads the all-time series with Tom Izzo, 3-12.

Duke vs Michigan State Prediction | March Madness Picks and Bracketology

In Coach K’s final hurrah, he gets another matchup with Tom Izzo and his Spartans. This is a rivalry he has dominated, winning 12 of 15 games, and the college basketball betting odds believe he will do it again.

In the First Round, Duke was able to coast against CS Fullerton. While they didn’t cover the spread, they were never in any real danger. Michigan State, on the other hand, had to fight to the final seconds against Davidson. A career performance from Sam Hauser was needed for the Spartans to move on.

It’s pretty obvious that Duke is the more talented team in this matchup. However, this Blue Devils team doesn’t have much grit and they can lose focus quickly. Instead of picking if they can finally cover a spread, we will bet the game total going over, as has been the trend for both teams.

Our college basketball betting Duke vs Michigan State prediction tonight will be the point total going OVER at BetUS

For what it’s worth, the ESPN Matchup Predictor gives Duke a 78.1% chance to win.

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