49ers vs Falcons Prediction, NFL Betting Trends, Odds and Week 6 Picks Against the Spread

One of the more unpredictable games on the Week 6 NFL slate is 49ers vs Falcons. Atlanta comes into the game as five-point underdogs despite having a perfect record against the spread. San Francisco has won big in three of their last four games. One of these streaks has got to give in Atlanta on Sunday, but which will it be?

This NFL betting preview will discuss our 49ers vs Falcons prediction, NFL betting trends, odds and Week 6 NFL picks against the spread. But first, let’s take a look at this exciting NFL betting signup offer at BetOnline Sportsbook.

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49ers vs Falcons Prediction | Week 6 NFL Picks Against the Spread

San Francisco 49ers (3-2, 1-2 Away) vs. Atlanta Falcons (2-3, 1-1 Home)
Date: Sunday, Oct. 16, 2022
Time: 1:00 PM EST
Venue: Mercedes-Benz Stadium — Atlanta, GA
Coverage: FOX

QB Comparison: 49ers – Jimmy Garoppolo (65/107, 857 Yds, 5 TD, 1 INT) | Atlanta – Marcus Mariota (71/123, 926 Yds, 4 TD, 4 INT)

The San Francisco offense has not been impressive this season but has not needed to be as the defense has played its way into being the best in the league. It is also understandable why they might not be as effective yet as they will be soon, given the fact that Kyle Shanahan spent the entire off-season and preseason tailor-making a playbook for a quarterback who could not be any more different than Jimmy Garoppolo. Lucky for them, the 49ers have benefited from a very soft schedule, and though Atlanta is far from a juggernaut, they have proven to be pesky and have the ability to win against anyone. The 49ers offense will need to show up if they hope for a win in this one.

Many people had Atlanta penciled in as a bottom feeder in the NFL this season. Despite only winning two games, the Falcons are actually a good team, and are on an incredible run against the spread. They have used Mariota efficiently, and are finding ways to replace the production lost via Cordarrelle Patterson injury. Their biggest flaw is not using Kyle Pitts. The former fourth selection in the 2021 NFL Draft has just one touchdown in his 20-game career, and a sickening total of 10 receptions on the year. If the Falcons would like to start winning instead of just covering, they must get Pitts involved in a big way.

49ers vs Falcons Prediction, NFL Betting Trends, Odds and Week 6 Picks Against the Spread — Credit: Credit: John McCoy/Getty Images

49ers vs Falcons Prediction, NFL Picks Against the Spread and Betting Odds

NFL betting odds for 49ers vs Falcons are taken from BetOnline Sportsbook.

Moneyline: SF: (-220) | ATL: (+190)
Spread: SF: -5 (-110) | ATL: +5 (-110)
Total: 44.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting via Action Network: SF: (59%) | ATL: (41%)

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NFL Betting Trends for 49ers vs Falcons

The 49ers are 3-2 in NFL picks against the spread (ATS) this season.
The OVER is 1-4 in San Francisco’s games this season.
The Falcons are 5-0 in NFL picks ATS this season.
The OVER is 3-2 in Atlanta’s games this season.

49ers vs Falcons s Stats

San Francisco averages 21.6 points per game (PPG) this season (T-No. 16 in the NFL).
San Francisco surrenders 12.2 PPG this season (T-No. 1 in the NFL).
Atlanta averages 23.6 PPG this season (No. 10 in the NFL).
Atlanta surrenders 24.4 PPG this season (T-No. 20 in the NFL).