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Wake Forest vs Duke Prediction and College Basketball Betting Picks

In an ACC college basketball matchup today, the Wake Forest Demon Deacons are taking on the ninth-ranked Duke Blue Devils at Cameron Indoor Stadium. Let’s take a look at the top college basketball betting odds, picks, betting trends and KenPom Rankings, then give our Wake Forest vs Duke prediction for the game today. 

Wake Forest vs Duke Game Info

Wake Forest Demon Deacons (20-6, 10-5 ACC) vs. No. 9 Duke Blue Devils (21-4, 11-3 ACC)
Date: Tuesday, February 15, 2022
Time: 7 PM ET
Venue: Cameron Indoor Stadium — Durham, NC
Coverage: ESPN

Wake Forest vs Duke Prediction and College Basketball Betting Picks
Credit: Rob Kinnan/USA TODAY Sports

Wake Forest vs Duke College Basketball Betting Picks and Odds

All college basketball betting odds can be found at BetUS Sportsbook

Moneyline: WAKE: (+450) | DUKE: (-600)
Point Spread: WAKE: +10.5 (-110) | DUKE: -10.5 (-110)
Total: 150 — Over: (-110) | Under: (-110)

KenPom Rankings

KenPom Rankings are from KenPom.com

TeamRkAdjOAdjDAdjT
Wake Forest37110.194.870.1
Duke7116.691.068.0

College basketball betting odds are found at BetUS. Click the link to claim a deposit bonus up to $3,125!


  • Wake Forest is 7-2 against the spread (ATS) in their last nine games.
  • The Demon Deans are 0-10 straight up in their last 10 road games against Duke.
  • Wake Forest is 4-1 ATS in their last five road games.
  • Duke is 4-2 ATS in their last six games.
  • The total has hit the OVER in Duke’s last five games against Wake Forest.
  • Duke is 7-1 straight up in their last eight games.

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Wake Forest vs Duke Prediction | College Basketball Betting Picks

Wake Forest faces the difficult task of playing in Cameron tonight. They have lost 10 straight road games against Duke, and another one looks to be on the horizon. Aside from a last-second three to lose against Virginia, Duke has been hot lately, with 12 of their last 14 wins being by double-digits.

A little over a month ago, Duke got a 76-64 road win against Wake Forest. This was another double-digit-point win despite shooting only 53.8% from the free throw line and sending the Demon Deacons to the line seven more times.

Look for this to be yet another double-digit win for Duke.

Our college basketball betting Wake Forest vs Duke prediction tonight will be Duke covering the spread at BetUS

For what it’s worth, the ESPN Matchup Predictor gives Duke an 86.1% chance to win.


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