In a March Madness Sweet 16 NCAA Tournament game, the 2-seed Villanova Wildcats will face off with the 11-seed Michigan Wolverines in the South Region. Let’s take a look at the top college basketball betting odds, picks, bracketology, betting trends and KenPom Rankings, then give our Villanova vs Michigan prediction for the game today. 

Villanova vs Michigan | March Madness Sweet 16

2022 NCAA Tournament Sweet 16
No. 2 Villanova Wildcats (28-7) vs. No. 11 Michigan Wolverines (19-14)
Date: Thursday, March 24, 2022
Time: 7:29 PM EST
Venue: AT&T Center — San Antonio, TX
Coverage: TBS

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Villanova vs Michigan College Basketball Betting Picks and Odds

All college basketball betting odds for Villanova vs Michigan can be found at BetUS Sportsbook.

Moneyline: NOVA: (-220) | MICH: (+180)
Point Spread: NOVA: -5 (-110) | MICH: +5 (-110)
Total: 135 — Over: (-110) | Under: (-110)


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Credit: Brian Fluharty/USA TODAY Sports

KenPom Rankings | Bracketology

KenPom Rankings are from KenPom.com

TeamRkAdjOAdjDAdjT
Villanova11118.393.662.6
Michigan27114.497.666.7
  • Wildcats are 17-4 ATS in their last 21 NCAA Tournament games as a favorite.
  • Wildcats are just 1-6 ATS in their last seven games following an ATS win.
  • The UNDER is 7-0 in the Wildcats last seven games following an ATS win.
  • Wolverines are 9-1-1 ATS in their last 11 neutral site games as an underdog.
  • Wolverines are just 1-7 ATS in their last eight games following an ATS win.
  • The total has gone OVER in each of the Wolverines’ last five games as an underdog.

Villanova vs Michigan Prediction | March Madness Sweet 16 Picks

Every year, the NCAA Tournament Selection Committee seems to get away with putting an undeserving team in the bracket. Not only did the committee elect to include Michigan in this year’s field, but they allowed the Wolverines to bypass the First Four as well. In an eerily similar resemblance to Syracuse teams of years gone by, Michigan has parlayed their fortunate at-large bid into a Sweet 16 appearance.

With that being said, Villanova will easily provide the Wolverines with their toughest test to date. From a coaching standpoint, Jay Wright is a mismatch for almost anyone. Juwan Howard figures to be no exception. Having won two of the last five editions of the NCAA Tournament, the Wildcats have been one of the most successful programs in the country in recent years. Led by two experienced and extremely talented guards in Collin Gillespie and Justin Moore, the Big East Tournament champs are more than capable of another Final Four appearance.

One area in which Michigan does figure to have a personnel advantage is in the frontcourt. Hunter Dickinson and Moussa Diabate present a difficult size matchup for a guard-dominated Wildcats team. Knowing that the Wolverines’ edge comes in the post, having this Sweet 16 matchup play out as a half-court slugfest would be ideal.

While Michigan figures to have no qualms about slowing things down based on the matchup, Villanova has been one of the 15 slowest teams on average this season. Despite the high level of offensive execution on both sides, the anticipated tempo suggests that betting the total under is the way to go.

Our college basketball betting Villanova vs Michigan prediction tonight will be UNDER 135 at BetUS

For what it’s worth, the ESPN Matchup Predictor gives Villanova a 76.5% chance to win.


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Henry’s passion for sports dates all the way back to childhood and has ultimately led to a full-fledged career as an analyst and content creator. After getting his start penning fantasy football articles, he forrayed into the betting side of the business in early 2019. His love for sports and statistics proved to be an ideal match with the dedicated research and strategy that handicapping requires. Henry currently specializes in betting analysis and picks for college football, college basketball and NASCAR. He counts the NFL, the WNBA, and NBA player props as additional leagues/markets of interest. Henry graduated from SUNY Buffalo in 2021 with a Communication Studies degree and a Psychology minor. A native of the Finger Lakes region in Upstate New York, he and his pup, Harold, have since relocated to Laramie, Wyoming. Thanks to his professional goals within the sports betting industry, there has been a whole lot of steam on the odds for a move to Las Vegas in 2023! Most of Henry’s free time is spent on outdoor adventures, playing chess, snowboarding, or reading a good book. He is also a competitive powerlifter and aspires to qualify for the USAPL Nationals meet within the next 2-3 years.

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