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Steelers vs Bills NFL Betting Odds, Trends and Picks for Week 1

Both the Pittsburgh Steelers and Buffalo Bills looked like contenders in the AFC last season. Unfortunately, both suffered disappointing exits from the playoffs. Reloading for an important 2021 season for both franchises, this Steelers vs Bills NFL betting matchup figures to be one of the best of the opening weekend. Which team will start the year off with an important win?

The following Steelers vs Bills NFL betting preview will give you the current odds, betting trends and picks for the Week 1 matchup.

Steelers vs Bills Week 1 NFL Betting Preview

NFL Regular Season — Week 1 Game
Pittsburgh Steelers (0-0, 0-0 Away) vs. Buffalo Bills (0-0, 0-0 Home)
Date: Sunday, September 12, 2021
Time: 1:00 p.m. EST
Venue: Highmark Stadium — Orchard Park, NY
Coverage: CBS

After mulling retirement, Ben Roethlisberger is back to lead this Steelers offense. Many forget that this is a Pittsburgh team that started last season 11-0, so it’d be foolish to count them out of any game. Still, the biggest question mark is their offensive line, and they must prove to everyone, including themselves, that they can be trusted. Defensively, this will again be one of the best units in the league, and T.J. Watt is a legitimate Defensive Player of the Year candidate. 

Josh Allen has taken notable steps forward every season, as has the rest of the Bills. The next goals on that last should be an NFL MVP and a Super Bowl birth, which are both very possible for this team. The offense will be one of the most explosive in the entire league, and the defense added more talent this offseason. The Bills must be able to stop the run and find a way to generate pressure this season, if they want to take those steps forward as a team.

nfl betting odds picks trends steelers vs bills
Credit: Tim Heitman/USA TODAY Sports

Steelers vs Bills Odds & Spread

NFL betting odds for Steelers vs Bills are taken from FanDuel Sportsbook.

Moneyline: PIT: (+240) | BUF: (-295)
Spread: PIT: +6.5 (-110) | BUF: -6.5 (-110)
Total: 48.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages via oddsFire: PIT: (36%) | BUF: (63%)
Odds to Win Super Bowl LVI: PIT: (+4400) | BUF: (+1200)

Steelers vs Bills NFL Betting Trends

– Pittsburgh was 10-7 against the spread (ATS) in its 17 games last season.
– The over was 8-7-2 for Pittsburgh last season.
– Buffalo was 12-7 ATS in its 19 games last season.
– The over was 12-6-1 for Buffalo last season.

Steelers vs Bills Stats

– Pittsburgh averaged 26.6 points per game (PPG) last season (No. 12 in the NFL).
– Pittsburgh surrendered 21.2 PPG last season (No. 5 in the NFL).
– Buffalo averaged 29.9 PPG last season (No. 3 in the NFL).
– Buffalo surrendered 23.2 PPG last season (T-No. 14 in the NFL).

Steelers vs Bills Prediction

The Steelers vs Bills NFL betting prediction uses the NumberFire Picks tool.

Steelers +6.5: 47.1%
Bills -6.5: 52.9%

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