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Louisville vs Notre Dame Prediction and College Basketball Betting Picks

In today’s ACC college basketball matchup, the Louisville Cardinals are taking on the Notre Dame Fighting Irish at Purcell Pavillion. Let’s take a look at the top college basketball betting picks and betting trends, then give our Louisville vs Notre Dame prediction for the game today. 

Louisville vs Notre Dame Game Info

Louisville Cardinals (11-12, 5-8 ACC) vs. Notre Dame Fighting Irish (16-7, 9-3 ACC)
Date: Wednesday, February 9, 2022
Time: 7 PM ET
Venue: Purcell Pavilion — South Bend, IN
Coverage: ESPNU

Louisville vs Notre Dame Prediction and College Basketball Betting Picks
Credit Matt Cashore/247 Sports

Louisville vs Notre Dame College Basketball Betting Picks and Odds

All college basketball betting odds for Louisville vs Notre Dame can be found at BetUS

Moneyline: LOU: (+260) | ND: (-320)
Point Spread: LOU: +7 (-110) | ND: -7 (-110)
Total: 135.5 — Over: (-110) | Under: (-110)


College basketball betting odds are found at BetUS. Click the link to claim a deposit bonus up to $3,125!


  • Louisville is 0-5 against the spread (ATS) in their last five games.
  • The Cardinals are 0-5 straight up in their last five games.
  • Notre Dame is 5-1 ATS in their last six games.
  • The total has hit the UNDER in four of Notre Dame’s last five games.
  • Notre Dame is 10-1 straight up in their last 11 home games.
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Louisville vs Notre Dame Prediction | College Basketball Betting Picks

Clearly, these teams are performing at very different levels right now. Louisville has lost five straight games, with three of the losses being by double-digits. On the other side, Notre Dame only has two losses in their last 14 games. They only have a single home loss this season, and that came against Duke.

This ACC matchup is a rematch from a couple of weeks ago. Thanks to 22 points from Blake Wesley, the Fighting Irish got a 12-point road win.

I’m expecting a similar result on Wednesday night in South Bend.

Our college basketball betting Louisville vs Notre Dame prediction tonight will be Notre Dame COVERS at BetUS

For what it’s worth, the ESPN Matchup Predictor gives Notre Dame an 83.9% chance to win.


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