The late-afternoon window of action on the Week 3 NFL slate features the game with the largest point spread. The winless New York Jets are catching double-digit points for their matchup at the Indianapolis Colts. The spread for this AFC East-AFC South showdown has been steadily climbing throughout the week and may not be done moving just yet. The NFL odds and expert NFL picks are heavily in favor of the home team.

This betting preview will give you the full scoop on the NFL odds and best NFL picks for the Week 3 Jets vs. Colts showdown on Sunday afternoon.

Credit: Andy Lyons/Getty Images

Jets vs. Colts Week 3 Sunday Afternoon

New York Jets (0-2, 0-1 Away) vs. Indianapolis Colts (1-1, 1-0 Home)
Date: Sunday, Sept. 27, 2020
Time: 4:05 p.n. EST
Venue: Lucas Oil Stadium – Indianapolis, IN
Coverage: CBS
Attendance: A maximum of 7,500 fans will be allowed to attend

Jets vs. Colts NFL Odds

All odds taken from Bovada Sportsbook

Opening Lines: Colts -6.5; O/U 45
Moneyline: NYJ: (+400) | IND: (-600)
Spread: NYJ: +11.5 (-110) | IND: -11.5 (-110)
Total: 44 — Over: (-110) | Under: (-110)

Jets vs. Colts Overview

Just when it seemed like things couldn’t get any worse for the New York Jets, they did. After taking a beating in Week 1 at the hands of the Buffalo Bills, a game that looked much closer on the final scoreboard than it actually was, the Jets were embarrassed at home by a banged-up San Francisco 49ers team. New York surrendered an 80-yard touchdown run on the very first series and would later allow the Niners to convert on a 3rd-and-31 attempt. Yikes.

The Jets will be facing an uphill battle as they look to overcome the NFL odds in Week 3 agaisnt the Colts. A growing list of injuries seems to signify that the team’s state of misery will be prolonged for at least the near future. Le’Veon Bell and Jamison Crowder, the most notable casualties from Week 1, were joined on the injury report this week by Breshad Perriman. With rookie Denzel Mims still on IR and yet to make his NFL debut, the Jets will be trotting out reserves at nearly every single offensive skill position. That’s right, Frank Gore, Chris Hogan, and Braxton Berrios will be starting in an NFL game this week. Sam Darnold doesn’t have a chance.

Week 1 was also dismal for the Indianapolis Colts as they were upset by their AFC South rivals in Jacksonville. The Colts managed to rebound nicely in Week 2, earning a comfortable home win over the Minnesota Vikings. It was a run-heavy approach from the start, and you can expect a heavy dose of Jonathan Taylor once again this week. While New York was actually a strong defense against the run last season, there are several injuries throughout the defensive front. With their strong offensive line, the Colts should have no trouble pounding the ball up the middle.

If the Colts are going to contend in the division and AFC this year, they are going to need better performances from Phillip Rivers. The veteran free agent acquisition has thrown one more interception (3) than touchdowns (2) through his first two games as a Colt. With Parris Campbell now set to miss time with a knee injury, expect T.Y. Hilton and rookie Michael Pittman to see plenty of targets. Nyheim Hines and whoever is suiting up at tight end will also be regularly involved in the passing attack.

Jets vs. Colts Betting Trends

  • Jets 2020 Betting Trends: 0-2 ATS; 2-0 to the Over
  • Colts 2020 Betting Trends: 1-1 ATS; 1-1 to the Over
  • The Jets are 4-1 ATS in their last five head-to-head meetings against the Colts.
  • The Over has hit in seven of the last nine meetings between the teams.

Jets vs. Colts Stats

  • New York has averaged 15.0 points per game (PPG) this season (No. 31 in the NFL)
  • New York has surrendered 29.0 PPG this season (No. 24 in the NFL)
  • Indianapolis has averaged 24.0 PPG this season (No. 18 in the NFL)
  • Indianapolis has surrendered 19.0 PPG this season (No. 8 in the NFL)

Jets vs. Colts NFL Picks and NFL Odds

All odds taken from Bovada Sportsbook

Prop Bet

First Half Spread: Colts -7

All signs point to a lopsided affair in this one. If the Jets are going to wind up covering the large spread, the only way I see them getting it done is through a backdoor cover. So long as the Colts starters are on the field and playing with focus and intensity, Indianapolis is clearly the better team. This will assuredly be the case in the first half. The Colts should have no trouble building a sizable lead over the first 30 minutes. With the NFL odds on the first half spread only being a single touchdown, this pick feels like a layup.

Jets vs. Colts NFL Picks + NFL Odds

To put it simply, Adam Gase and the Jets have not given us any reason to feel good about backing them at the betting window. When you combine the impactful injuries, locker room dissension, and general talent mismatches together, it’s hard to envision New York even being competitive against a Colts team whose strengths reside along the line of scrimmage on both sides of the ball.

The opening line of Colts -6.5 is long, long gone. Even so, 11.5 feels very coverable. After what we saw out of the Jets last week, I’d be comfortable laying up to two touchdowns with the Colts in this one (Colts -13.5 as an alternate spread has +100 odds at FanDuel Sportsbook). With that said, the regular spread is my game pick here.

NFL Odds Pick: Colts -11.5

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Henry’s passion for sports dates all the way back to childhood and has ultimately led to a full-fledged career as an analyst and content creator. After getting his start penning fantasy football articles, he forrayed into the betting side of the business in early 2019. His love for sports and statistics proved to be an ideal match with the dedicated research and strategy that handicapping requires. Henry currently specializes in betting analysis and picks for college football, college basketball and NASCAR. He counts the NFL, the WNBA, and NBA player props as additional leagues/markets of interest. Henry graduated from SUNY Buffalo in 2021 with a Communication Studies degree and a Psychology minor. A native of the Finger Lakes region in Upstate New York, he and his pup, Harold, have since relocated to Laramie, Wyoming. Thanks to his professional goals within the sports betting industry, there has been a whole lot of steam on the odds for a move to Las Vegas in 2023! Most of Henry’s free time is spent on outdoor adventures, playing chess, snowboarding, or reading a good book. He is also a competitive powerlifter and aspires to qualify for the USAPL Nationals meet within the next 2-3 years.

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