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Iowa vs Iowa State College Football Betting Odds and Picks for Week 2

After an exciting first weekend football, we have another solid college football betting slate in Week 2 of the season. One of the more high-profile matchups is an in-state battle between the Iowa Hawkeyes and Iowa State Cyclones. Both schools won their Week 1 matchup and find themselves ranked in the top 10.

Iowa will look to continue its dominance over Iowa State in Ames this weekend. Cyclone tight end and All-American candidate Charlie Kolar missed last week’s game versus Northern Iowa. All signs are pointing towards his return this weekend, which would be a huge lift for Matt Campbell and his team.

Let’s take a look at this Iowa vs Iowa State matchup from a college betting perspective, including odds and picks.

college football betting picks odds iowa vs iowa state
Credit: Michael Hickey/Getty Images

Iowa vs Iowa State College Football Betting Odds and Picks For Week 2

No. 10 Iowa (1-0) vs No. 9 Iowa State (1-0)
Date: Saturday, September 11th, 2021
Time: 4:30 PM ET
Venue: Jack Trice Stadium — Ames, Iowa
Coverage: ABC

College Football Betting Odds

Moneyline: IOWA (+165) | ISU (-195)
Spread: IOWA +4.5 (-115) | ISU -4.5 (-105)
Total: 46 — Over (-110) | Under (-110)

Iowa vs Iowa State Picks

Iowa 24, Iowa State 21 (Iowa +4.5, Under 46)

Iowa crushed Indiana’s dreams of another great season last weekend. Running back Tyler Goodson rushed for 99 yards and a touchdown on only 19 carries. He is the most explosive player on the Hawkeyes. The defense is where Iowa really stood out. Defensive back Riley Moss had two interceptions, returning both for touchdowns. However, the defensive line will need to find a way to put pressure on the cool and collected Brock Purdy. Defensive lineman Lukas Van Ness is the only player in the front seven to have a sack. They will need quite a few more than that to retain the Cy-Hawk trophy.

The Cyclones did not look good against Northern Iowa on Saturday, but that is nothing new to head coach Matt Campbell. Iowa State always plays slow to open the season, but they finish strong. However, to get a hold of the Cy-Hawk trophy, they will need to get Breece Hall going. Last week, the Heisman contender had only 69 yards on 23 carries but did find the end zone once. That is shockingly low for a guy who rushed for over 1,500 yards last year. Quarterback Brock Purdy is as solid as it gets. On defense, O’Rien Vance and defensive lineman Will McDonald IV were the only two defenders to notch a sack against the Panthers. Datrone Young and Isheem Young both notched interceptions.

This game will start slow but pick up near the end. The official college football betting picks is Iowa to win outright and cover the spread against their in-state rivals.


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