The Iowa State Cyclones and South Dakota State Jackrabbits will face off in the first round of the 2024 NCAA Basketball Tournament. Iowa State enters March Madness as winners of three, all coming on their path to a Big 12 Tournament championship. In that title game, the Cyclones made one of the biggest statements of the college basketball season, beating 1-seed Houston by 28. South Dakota State enters the NCAA Tournament with an eight game winning streak, including three straight to win the Summit League championship. Below, we will preview this NCAA Tournament college basketball game, giving an Iowa State vs South Dakota State prediction using trends, data, and analysis.

Which school will win and keep their hopes of winning the championship trophy alive?

Iowa State vs South Dakota State Prediction and March Madness Expert Picks

2024 NCAA Tournament
No. 2 Iowa State Cyclones (27-7) vs. No. 15 South Dakota State Jackrabbits (22-12)
Date: Thursday, March 21, 2024
Time: 7:35 PM EST
Venue: CHI Health Center — Omaha, NE
Coverage: TruTV

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Iowa State vs South Dakota State March Madness Odds

All college basketball betting odds for Iowa State vs South Dakota State can be found at BetUS Sportsbook.

Moneyline: ISU: (-2000) | SDS: (+1000)
Point Spread: ISU: -16.5 (-110) | SDS: +16.5 (-110)
Total: Over: 135.5 (-110) | Under: 135.5 (-110)

KenPom Rankings | Bracketology

KenPom Rankings are from KenPom.com

TeamRkAdjOAdjDAdjT
Iowa State5113.9 (55)87.1 (1)67.3 (179)
South Dakota St134108.7 (134)105.7 (163)67.9 (148)

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  • Iowa State is 11-2 in non-conference college basketball games this season. 
  • South Dakota State is 4-8 in non-conference college basketball games this season. 
  • Iowa State is 23-10-1 against the spread this year. 
  • This will be South Dakota State’s fifth NCAA Tournament appearance since 2016.

Iowa State vs South Dakota State Prediction | March Madness Expert Picks

Entering Selection Sunday, many people were wondering if Iowa State could steal the fourth 1-seed from North Carolina following their dominant Big 12 Tournament run. Instead, the Cyclones ranked eighth overall in the eyes of the committee and were given a 2-seed in UConn’s region. They boast the top-ranked defense per KenPom and excel in every area on that side of the ball. They have excellent ball pressure from guards Tamin Lipsey and Keshon Gilbert, force over 17 turnovers per game (second-best nationally), and finish possessions with strong defensive rebounding. Offensively, Lipsey, Gilbert, and freshman Milan Momcilovic lead the team in scoring; however, Iowa State can get points from a variety of sources on any given day.

South Dakota State is one of the more efficient shooting teams in the nation. They shoot it from beyond the arc at a 36.2% clip which ranks inside the top 50 nationally. The Jackrabbits rank 19th in the country with a 55.3 eFG%. They have played one other NCAA Tournament team, Akron, and lost 81-75.

In this game, Iowa State head coach T.J. Otzelberger will be going against his former team for the first time. His Cyclones should overmatch the Jackrabbits in this one in every aspect of the game. It will be hard for any mid-major to generate consistent looks against the vaunted Iowa State defense. For our Iowa State vs South Dakota State prediction, we are picking the Iowa State Cyclones to win and move on in the NCAA Tournament.

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