In a First Round NCAA Tournament matchup, the (6) Iowa State Cyclones will take on the (11) Pittsburgh Panthers in the Midwest Region. Let’s take a look at the college basketball betting odds, March Madness expert picks, betting trends, and KenPom rankings, then give our Iowa State vs. Pittsburgh prediction.

Iowa State vs Pittsburgh Prediction and March Madness Expert Picks

2023 NCAA Tournament
No. 6 Iowa State (19-13) vs. No. 11 Pittsburgh (23-11)
Date: Friday, March 17, 2023
Time: 3:10 P.M. EST
Venue: Greensboro Coliseum – Greensboro, NC
Coverage: TruTV

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Iowa State vs Pittsburgh March Madness Betting Odds

All college basketball betting odds for Houston vs Northern Kentucky can be found at BetUS Sportsbook.

Moneyline: IS: -175 | PITT: +150
Point Spread: IS: -4 (-110) | PITT: +4 (-110)
Total: 131 – OVER: -110 | UNDER: -110

KenPom Rankings | Bracketology

KenPom Rankings are from KenPom.com

TeamAdjEM (Rk)AdjO (Rk)AdjD (Rk)AdjT (Rk)
Iowa State+18.36 (24)109.9 (96)91.6 (9)64.3 (327)
Pittsburgh+11.47 (77)115.0 (24)103.5 (135)67.2 (176)

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  • Iowa State is 16-16 against the spread (ATS) this season.
  • Pittsburgh is 23-10-1 ATS this season.
  • The OVER is 11-21 for Iowa State this season.
  • The OVER is 21-13 for Pittsburgh this season.

Iowa State vs Pittsburgh Prediction | March Madness Expert Picks

A tall of two teams – especially in regards to the OVER hitting for these teams. Iowa State rarely hits the over in their games, while it seems like Pittsburgh hits the OVER in almost every single one of their games. That alone makes me not want to touch the total for the bet.

Instead, I think we should look at the spread. Pittsburgh did not exactly have a great game against Mississippi State and probably should have lost that game. While Pittsburgh is not really that great of a team, what they are great at is keeping games close and covering the spread. We know that Iowa State wants to slow the game and play physical defense, which is something that I don’t know if Pittsburgh can overcome. While they will get to the free throw line, I think that Pitt is going to need a big day from the 3-point line to win this game. I think Pittsburgh keeps the game close, but ultimately ends up losing.

Our college basketball betting Iowa State vs Pittsburgh prediction tonight will be Pittsburgh +4 hitting at BetUS

For what it’s worth, the ESPN Matchup Predictor gives Iowa State a 66.9% chance to win.


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From Green Bay, Wisconsin. NBA, College Basketball, MLB and NFL Fan/Writer. UW-La Crosse Graduate. Watch Sports, Play Basketball and Travel in Free Time. Love to go Fishing. Go Tar Heels.

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