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Colts vs Dolphins NFL Betting Odds, Trends, Stream and Picks for Week 4

Henry John by Henry John
September 30, 2021
in Betting, NFL
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Among the notable NFL betting matchups in Week 4 is this showdown between two AFC teams desperate for a victory. The Indianapolis Colts will look to notch their first victory of the year in their fourth attempt this Sunday when they travel to South Florida to take on the Miami Dolphins. After suffering their second consecutive defeat last week, the Dolphins will also be gunning to get their season back on track. The NFL betting odds offer a slim edge to the home team ahead of this Colts vs Dolphins contest.

The following Colts vs Dolphins NFL betting preview will give you the current odds, betting trends and picks for the Week 4 matchup, along with a stream link to watch games all season long.

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Colts vs Dolphins Week 4 NFL Betting Preview

NFL Regular Season — Week 4 Game
Indianapolis Colts (0-3, 0-1 Away) vs. Miami Dolphins (1-2, 0-1 Home)
Date: Sunday, Oct. 3, 2021
Time: 1 p.m. EST
Venue: Hard Rock Stadium — Miami Gardens, FL
Coverage: Click here for the stream

Indianapolis Colts Preview

The first three weeks have gone very badly for a Colts team that aspired to win the AFC South Division coming into the year. Not only are they now 0-3 but the most recent defeat came courtesy of the division rival Tennessee Titans. The fact that Carson Wentz was even able to start last Sunday’s NFL betting matchup after spraining both ankles in Week 2 is borderline incredible. Unfortunately, he was quite ineffective, finishing just 19/37 passing for 194 yards. Wideout Michael Pittman Jr. led the team with 68 yards receiving but caught only six of 12 targets. T.Y. Hilton is reportedly getting closer to making his return, but that won’t happen this week. Indianapolis’ lack of receiver depth has shown in his absence.

The other real concern for the Colts after three games is the regression of the defense. While the unit has been fairly stout against the run, they rank just 29th in adjusted efficiency against the pass entering their Week 4 NFL betting contest. That said, the Colts’ defense did come away with three takeaways last week, including interceptions by Kenny Moore and Darius Leonard. Too bad the offense failed to capitalize on them. 

Miami Dolphins Preview

With second-year QB Tua Tagovailoa landing on IR, the Dolphins handed the reigns to former Colts signal-caller Jacoby Brissett last week. He acquitted himself quite well, passing for 215 yards and playing a turnover-free game in the team’s overtime loss to the Las Vegas Raiders. If anything, Brissett seemed to fall victim to conservative play-calling whenever Miami took the lead. One need not look any further than rookie wideout Jaylen Waddle’s stat line for supporting evidence. Waddle had a full dozen receptions last week, yet finished with only 58 yards receiving. That equates to an average of 4.8 yards per reception. Talk about Charlie Checkdown!

In reality, Brissett is actually more willing and capable of pushing the ball down the field than Tagovailoa. How these next couple of games go could be huge in dictating whether or not the latter regains the starting job upon returning from IR. Brissett also brings some rushing ability, particularly in short-yardage situations. He did record a rushing touchdown in last week’s NFL betting loss. Tight end Mike Gesicki also had a busy game with 10 catches for a team-leading 86 yards. Brandon Jones picked up a pair of sacks last week to lead a defense that ranks seventh in overall adjusted efficiency, per Football Outsiders. 

Jacoby Brissett NFL betting trends odds picks Colts vs Dolphins
Credit: Michael Reaves/Getty Images

Colts vs Dolphins Odds and Spread

NFL betting odds for Colts vs Dolphins are taken from BetMGM Sportsbook.

Moneyline: IND: (+105) | MIA: (-125)
Spread:
IND: +2 (-110) | MIA: -2 (-110)
Total:
42 — Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages
via Action Network: IND: (41%) | MIA: (59%)

Colts vs Dolphins NFL Betting Trends

  • The Colts are 1-2 ATS and 1-2 to the over this season.
  • The Dolphins are 2-1 ATS and 1-2 to the over this season.
  • Six of the Colts’ last eight road games have gone over the total.
  • Dolphins are 6-1 ATS in their last seven home games.
  • Colts are 6-2 SU in their last eight head-to-head meetings against the Dolphins.

Colts vs Dolphins Stats

  • Indianapolis is averaging 18.7 points per game (PPG) this season (Tied for No. 24 in the NFL).
  • Indianapolis is surrendering 26.7 PPG this season (No. 22 in the NFL).
  • Miami is averaging 15.0 PPG this season (No. 30 in the NFL).
  • Miami is surrendering 27.3 PPG this season (No. 23 in the NFL).

Signup for BetMGM Sportsbook today for a risk-free bet up to $1,000!


Colts vs Dolphins Prediction

The Colts vs Dolphins NFL betting prediction uses the ESPN Football Power Index.

Colts: 43.4%
Dolphins:
56.2%
Tie:
0.3%


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Tags: Carson WentzDarius LeonardIndianapolis ColtsJacoby BrissettJaylen WaddleKenny MooreMiami DolphinsMichael Pittman Jr.Mike GesickiNFLNFL BettingSports BettingTua Tagovailoa
Henry John

Henry John

Henry John is a multi-sport analyst specializing in motorsports, football, and betting markets. His work focuses on performance trends, strategy, and data-driven insights to better understand outcomes and identify value. With experience producing content across multiple platforms, Henry has written extensively on NASCAR, college football, the NFL, and other major sports, developing structured analysis that goes beyond surface-level recaps. His approach blends statistical evaluation, betting market awareness, and game-level context to break down how and why results happen. Outside of sports, Henry enjoys strength training, outdoor activities, and continuous learning in analytics and performance.

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