For the first time since October of 2018, the Indianapolis Colts and Buffalo Bills will go head-to-head on Saturday afternoon as part of NFL Wild Card Weekend. This article contains the NFL betting preview for the NFL Playoffs matchup, including odds, spread, betting trends, start time and Colts vs Bills prediction.

Colts vs Bills Prediction and Betting Overview

Colts vs Bills NFL Playoffs Game Info

Indianapolis Colts (11-5, 5-3 Away) vs. Buffalo Bills (13-3, 7-1 Home)
Date: Saturday, Jan. 9, 2021
Time: 1:05 p.m. EST
Venue: Bills Stadium – Orchard Park, NY
Coverage: CBS

Credit: Joe Robbins/Getty Images

Colts vs Bills NFL Betting Odds

All NFL betting lines and odds are available on Bovada Sportsbook

 Moneyline: IND: (+255) | BUF: (-310)
Spread: IND: +7 (-120) | BUF: -7 (+100)
Total: 51.5 – Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages: IND: (14%) | BUF: (86%)
Odds to Win Super Bowl LV: IND: (+5000) | BUF: (+650)

  • The Colts are 2-4 ATS in their last six games.
  • The Bills are 8-0 ATS in their last eight games.
  • 11 of the Bills’ 16 games this season went Over the total.
  • The Bills are 4-2 ATS in their last six head-to-head games against the Colts.
  • Home teams have been the outright winner in each of the last six head-to-head games between the Colts and Bills.
  • Under the total has hit in each of the last four and seven of the last eight head-to-head games between the Colts and Bills.

Colts vs Bills Stats

  • Indianapolis is averaging 28.2 points per game (PPG) this season (No. 9 in the NFL).
  • Indianapolis is surrendering 22.6 PPG this season (No. 10 in the NFL).
  • Buffalo is averaging 31.3 PPG this season (No. 2 in the NFL).
  • Buffalo is surrendering 23.4 PPG this season (No. 16 in the NFL).

Colts vs Bills Prediction

This Colts vs Bills prediction is according to the ESPN Basketball Power Index (BPI).
Colts: 32.5%
Bills: 67.5%

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