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Colts vs Bills Playoffs Odds, Spread and Betting Trends for NFL Wild Card Weekend

Henry John by Henry John
January 6, 2021
in Betting, NFL
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For the first time since October of 2018, the Indianapolis Colts and Buffalo Bills will go head-to-head on Saturday afternoon as part of NFL Wild Card Weekend. This article contains the NFL betting preview for the Colts vs Bills playoff matchup, including odds, spread, and NFL betting trends for the AFC Wild Card matchup.

Colts vs Bills Playoffs Preview | NFL Betting Preview

Colts vs Bills Playoffs Game Info

Indianapolis Colts (11-5, 5-3 Away) vs. Buffalo Bills (13-3, 7-1 Home)
Date: Saturday, Jan. 9, 2021
Time: 1:05 p.m. EST
Venue: Bills Stadium – Orchard Park, NY
Coverage: CBS

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Credit: Tim Heitman/USA TODAY Sports

Colts vs Bills NFL Betting Odds

All NFL betting lines and odds are available on MyBookie Sportsbook

 Moneyline: IND: (+245) | BUF: (-305)
Spread: IND: +7 (-120) | BUF: -7 (+100)
Total: 51.5 – Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages: IND: (29%) | BUF: (71%)
Odds to Win Super Bowl LV: IND: (+5000) | BUF: (+650)

Colts vs Bills playoffs NFL betting game odds

Colts vs Bills NFL Betting Trends

  • The Colts are 2-4 ATS in their last six games.
  • The Bills are 8-0 ATS in their last eight games.
  • 11 of the Bills’ 16 games this season went Over the total.
  • The Bills are 4-2 ATS in their last six head-to-head games against the Colts.
  • Home teams have been the outright winner in each of the last six head-to-head games between the Colts and Bills.
  • Under the total has hit in each of the last four and seven of the last eight head-to-head games between the Colts and Bills.

Colts vs Bills Stats

  • Indianapolis is averaging 28.2 points per game (PPG) this season (No. 9 in the NFL).
  • Indianapolis is surrendering 22.6 PPG this season (No. 10 in the NFL).
  • Buffalo is averaging 31.3 PPG this season (No. 2 in the NFL).
  • Buffalo is surrendering 23.4 PPG this season (No. 16 in the NFL).
Tags: Buffalo BillsIndianapolis ColtsNFLNFL BettingNFL PlayoffsSports Betting
Henry John

Henry John

Henry John is a multi-sport analyst specializing in motorsports, football, and betting markets. His work focuses on performance trends, strategy, and data-driven insights to better understand outcomes and identify value. With experience producing content across multiple platforms, Henry has written extensively on NASCAR, college football, the NFL, and other major sports, developing structured analysis that goes beyond surface-level recaps. His approach blends statistical evaluation, betting market awareness, and game-level context to break down how and why results happen. Outside of sports, Henry enjoys strength training, outdoor activities, and continuous learning in analytics and performance.

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