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Colts vs 49ers NFL Betting Odds, Trends, Picks and Stream for SNF Week 7

NFL Sunday caps off with a Sunday Night Football matchup that is considered a “must-win” for both teams, despite it only being Week 7 of the season. The Indianapolis Colts will travel to take on the San Francisco 49ers, who are fresh off their bye. It is an interesting game for NFL betting for many reasons, so let’s jump right into it.

The following Colts vs 49ers NFL betting preview will give you the current odds, betting trends and picks for the Week 7 matchup, along with a stream link to watch games all season long.

Colts vs 49ers SNF Week 7 NFL Betting Preview and Stream

NFL Regular Season — Week 7 Sunday Night Football
Indianapolis Colts (2-4, 1-2 Away) vs. San Francisco 49ers (2-3, 0-2 Home)
Sunday, October 24, 2021
8:20 p.m. EST
Levi’s Stadium — Santa Clara, CA
Coverage: Click here for the stream

After losing their first three games of the season, the Colts have been more competitive the past three weeks. They have totaled two wins and an overtime loss over this span, though the wins have come against the Miami Dolphins and Houston Texans, while the overtime loss needed a massive collapse on their end to even go to extra time. Carson Wentz is getting healthier while the rest of the team is not. T.Y. Hilton is out once again, while the defense has also suffered some key injuries that will be tough to overcome.

The 49ers are fresh off their bye week, where they have been great in recent seasons, going 3-0 against the spread following a bye since 2019. Jimmy Garoppolo is back at quarterback, while George Kittle is still out. However, the backfield is getting healthier, which should take some pressure off of the passing game. Defensively, they live and die by their pass rush, which hasn’t been as elite as seasons past. Fred Warner is also a stud in the middle, but he cannot make every play, which is exactly what is needed for this defense to be considered scary.

colts vs 49ers nfl betting trends odds picks stream
Credit: Sports Illustrated

Colts vs 49ers Odds & Spread

NFL betting odds for Colts vs 49ers are taken from BetMGM Sportsbook.

Moneyline: IND: (+160) | SF: (-190)
 IND: +4 (-110) | SF: -4 (-110)
Total: 42.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting via Action Network: IND: (40%) | SF: (60%)
Odds to Win Super Bowl LVI: IND: (+10000) | SF: (+4000)

Colts vs 49ers NFL Betting Trends

– Indianapolis is 4-2 against the spread (ATS) this season.
– The Over is 3-3 for the Colts this season.
– San Francisco is 1-4 ATS this season.
– The Over is 2-3 for the 49ers this season.

Colts vs 49ers Stats

– Indianapolis is averaging 23.2 points per game (PPG) this season (No. 19 in the NFL).
– Indianapolis is surrendering 21.8 PPG this season (No. 11 in the NFL).
– San Francisco is averaging 23.4 PPG this season (No. 17 in the NFL).
– San Francisco is surrendering 23.8 PPG this season (No. 16 in the NFL).

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Colts vs 49ers Prediction

The Colts vs 49ers NFL betting prediction uses the ESPN Football Power Index.

Colts : 34.4%
49ers: 65.3%
Tie: 0.3%

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