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Chargers vs Chiefs Prediction, NFL Betting Trends and TNF Week 2 Picks Against the Spread

After a first week full of poor football and eventful finishes, we are onto NFL Week 2. We have an AFC West divisional matchup for Thursday Night Football, with the Los Angeles Chargers taking on the Kansas City Chiefs. It has been tough to make a Chargers vs Chiefs prediction over the past several seasons, with exciting games between these two teams.

This NFL betting preview will discuss our Chargers vs Chiefs prediction, NFL betting trends, odds and Week 2 NFL picks against the spread. But first, let’s take a look at this exciting NFL betting signup offer at BetOnline Sportsbook.

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Chargers vs Chiefs Prediction | Week 2 NFL Picks Against the Spread

Thursday Night Football — Week 2
Los Angeles Chargers (1-0, 0-0 Away) vs. Kansas City Chiefs (1-0, 0-0 Home)
Date: Thursday, Sept. 15, 2022
Time: 8:15 PM EST
Venue: Arrowhead Stadium — Kansas City, MO

CLICK HERE to claim a free 30-day trial of Amazon Prime Video so you can watch the Chargers vs Chiefs matchup on Thursday Night Football tonight.

Both the Chargers and the Chiefs enter this game 1-0, but it’s Kansas City who has a better vibe about them. The Chiefs’ offense looked unstoppable, as Patrick Mahomes looks to have the most talent around him he ever has. The Chargers, on the other hand, struggled during their final few drives against the Raiders. On top of that, Keenan Allen injured his hamstring and will miss the Chargers vs Chiefs TNF matchup. Will the Chargers’ defense step up and slow Mahomes down enough to keep this game close?

chargers vs chiefs prediction odds nfl picks against the spread
Credit: Jay Biggerstaff/USA TODAY Sports

Chargers vs Chiefs Prediction, NFL Picks Against the Spread and Betting Odds

NFL betting odds for Chargers vs Chiefs are taken from BetOnline Sportsbook.

Moneyline: LAC: (+170) | KC: (-195)
LAC: +4 (-110) | KC: -4 (-110)
54 — Over: (-110) | Under: (-110)
Public (Spread) Betting 
via Action NetworkLAC: (39%) | KC: (61%)

Chargers vs Chiefs NFL Betting Trends

  • The Chargers are 1-0 in NFL picks against the spread (ATS) this season.
  • The OVER is 0-1 in Los Angeles’ games this season.
  • The Chiefs are 1-0 in NFL picks ATS this season.
  • The OVER is 1-0 in Kansas City’s games this season.

Chargers vs Chiefs Stats

  • The Chargers average 24 points per game (PPG) this season (T-No. 9 in the NFL).
  • The Chargers surrender 19 PPG this season (T-No. 9 in the NFL).
  • Kansas City averages 44 PPG this season (No. 1 in the NFL).
  • Kansas City surrenders 21 PPG this season (T-No. 17 in the NFL).

Chargers vs Chiefs Prediction

This Week 2 NFL betting Chargers vs Chiefs prediction uses NumberFire’s game projections. They give Kansas City a 71.3% chance to win this Week 2 matchup.

The FlurrySports experts also have their own Week 2 NFL Picks here.

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