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Cardinals vs Rams NFL Betting Odds, Trends, Stream and Picks for Week 4

One of the most anticipated NFL betting matchups in Week 4 pits a pair of unbeaten divisional foes against one another. Both the Arizona Cardinals and Los Angeles Rams have opened the season with three straight wins. However, only one team can walk out of SoFi Stadium with their unblemished record intact. The NFL betting odds have made the home squad a pretty firm favorite ahead of Sunday’s Cardinals vs Rams showdown.

The following Cardinals vs Rams NFL betting preview will give you the current odds, betting trends and picks for the Week 4 matchup, along with a stream link to watch games all season long.

Cardinals vs Rams Week 4 NFL Betting Preview

NFL Regular Season — Week 4 Game
Arizona Cardinals (3-0, 2-0 Away) vs. Los Angeles Rams (3-0, 2-0 Home)
Date: Sunday, Oct. 3, 2021
Time: 4:05 p.m. EST
Venue: SoFi Stadium — Inglewood, CA
Coverage: Click here for the stream

Arizona Cardinals Preview

The Cardinals actually trailed at halftime of their Week 3 contest against the winless Jacksonville Jaguars. A 17-point third quarter served as the springboard to what was ultimately a double-digit win and a 3-0 start to the season. Quarterback Kyler Murray continues to fill up the box score seemingly every week. He eclipsed 300 yards passing last Sunday and also scored a rushing touchdown. James Conner also found the end zone twice on the ground. While Arizona did not record a single score through the air, that didn’t prevent both A.J. Green and Christin Kirk from topping 100 yards receiving on the day.

Perhaps the biggest surprise the Cardinals have thrown at NFL betting analysts through three weeks is their ability to defend the pass. Football Outsiders grades Arizona as the third-best defense for adjusted efficiency against the pass. Last week’s matchup undoubtedly helped boost some of their numbers. Byron Murphy intercepted Jaguars’ QB, Trevor Lawrence, twice, returning one for a touchdown. The Cardinals also had three sacks as a team. One also can’t help but wonder how things might be different had the Tennesse Titans actually shown up for the Week 1 showdown between the teams. The D will get undoubtedly its toughest test to date this Sunday.

Los Angeles Rams Preview

After dispatching of the reigning Super Bowl Champion Tampa Bay Buccaneers in convincing fashion last week, the Rams are now the talk of the NFL betting world. The team is suddenly on top of seemingly every NFL power rankings known to man. Matthew Stafford is now at the heart of MVP discussions. While everything is rosy right now in SoCal, L.A. faces a tough task in turning around to play a divisional matchup just one week after their big win. Will the headlines and praise get to them?

Seeing that the NFL betting odds have installed the Rams as a healthy five-point favorite is noteworthy. They certainly didn’t do anything against the Buccaneers to suggest that the spread should be much shorter than the six-point margin it was on the Las Vegas lookahead market last week. Stafford tore up the Tampa Bay secondary for 343 yards passing and four touchdowns. Two of those went to Cooper Kupp, who had yet another monster game with 96 yards on nine receptions. Even 34-year-old veteran DeSean Jackson got in on the aerial brigade. He caught a long touchdown and led the team with 120 yards receiving. The uber-talented Los Angeles defensive front got after Tom Brady all game long, sacking him three times.

Matthew Stafford Cardinals vs Rams NFL betting trends odds picks
Credit: AP Photo/Zach Bolinger

Cardinals vs Rams Odds and Spread

NFL betting odds for Cardinals vs Rams are taken from BetMGM Sportsbook.

Moneyline: ARI: (+175) | LAR: (-200)
ARI: +5 (-110) | LAR: -5 (-110)
54.5 — Over: (-115) | Under: (-105)
Public (Spread) Betting Percentages
via Action Network: ARI: (45%) | LAR: (55%)

Cardinals vs Rams NFL Betting Trends

  • The Cardinals are 2-1 ATS and 1-2 to the over this season.
  • The Rams are 2-1 ATS and 3-0 to the over this season.
  • Each of the Cardinals’ last eight road games has gone under the total.
  • Rams are 10-2 SU in their last 12 home games.
  • Rams are 7-0-1 ATS in their last eight head-to-head meetings against the Cardinals.

Cardinals vs Rams Stats

  • Arizona is averaging 34.3 points per game (PPG) this season (Tied for No. 1 in the NFL).
  • Arizona is surrendering 21.7 PPG this season (No. 11 in the NFL).
  • Los Angeles is averaging 31.7 PPG this season (No. 3 in the NFL).
  • Los Angeles is surrendering 20.7 PPG this season (No. 9 in the NFL).

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Cardinals vs Rams Prediction

The Cardinals vs Rams NFL betting prediction uses the ESPN Football Power Index.

Cardinals: 38.8%

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