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49ers vs Lions NFL Betting Odds, Trends and Picks for Week 1

While both the San Francisco 49ers and Detroit Lions both had disappointing 2020 season, both teams also had very different expectations. The same is true for 2021. San Francisco is viewed as a Super Bowl contender, while Detroit is fighting to not be last in the league. Will this 49ers vs Lions NFL betting matchup play out as most expect?

The following 49ers vs Lions NFL betting preview will give you the current odds, betting trends and picks for the Week 1 matchup.

49ers vs Lions Week 1 NFL Betting Preview

NFL Regular Season — Week 1 Game
San Francisco 49ers (0-0, 0-0 Away) vs. Detroit Lions (0-0, 0-0 Home)
Date: Sunday, September 12, 2021
Time: 1:00 p.m. EST
Venue: Ford Field — Detroit, MI
Coverage: FOX

After being decimated by injuries last season, the 49ers look like Super Bowl contenders yet again. On offense, it appears Kyle Shanahan is going to deploy a two-quarterback system, which could be genius or disastrous. Still, with the weapons this team has, the offense should be just fine. The defense has a few changes to personnel, but the biggest question that must be answered is if this unit takes a step backwards, following the departure of Robert Saleh, who accepted the Jets’ head coaching position. 

The Lions are looking at a complete overhaul, but it will be a process. Dan Campbell is the new head coach, and he looks to completely change the organization’s culture. Unfortunately, the team traded long-time quarterback Matthew Stafford away for Jared Goff, who doesn’t match this intended culture at all. He will be passing to the league’s worst receiving corps as well. Defensively, it doesn’t get much better. This will be a long season for Lions fans.

nfl betting trends odds picks 49ers vs lions
Credit: Raj Mehta/USA TODAY Sportsd

49ers vs Lions Odds & Spread

NFL betting odds for 49ers vs Lions are taken from FanDuel Sportsbook.

Moneyline: SF: (-330) | DET: (+270)
Spread: SF: -7.5 (-110) | DET: +7.5 (-110)
Total: 51.5 — Over: (-105) | Under: (-115)
Public (Spread) Betting Percentages via oddsFire: SF: (55%) | DET: (45%)
Odds to Win Super Bowl LVI: SF: (+1400) | DET: (+20000)

49ers vs Lions NFL Betting Trends

– San Francisco went 7-9 against the spread (ATS) last season.
– The over was 8-8 for San Francisco last season.
– Detroit went 7-9 ATS last season.
– The over was 10-6 for Detroit last season.

49ers vs Lions Stats

– San Francisco averaged 23.5 points per game (PPG) last season (No. 21 in the NFL).
– San Francisco surrendered 24.4 PPG last season (No. 17 in the NFL).
– Detroit averaged 23.6 PPG last season (No. 20 in the NFL).
– Detroit surrendered 32.4 PPG last season (No. 32 in the NFL).

49ers vs Lions Prediction

The 49ers vs Lions NFL betting prediction uses the NumberFire Picks tool.

49ers –7.5: 43.5%
Lions +7.5: 56.5%

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