For the second time this season, the Indianapolis Colts and Houston Texans are set to collide this Sunday afternoon. The AFC South Division rivals both enter Week 13 on the heels of a loss. However, the recent trends and future outlook for the two teams going forward this season are virtually polar opposites. The lopsided power ratings of the two sides are clearly reflected in the Colts vs Texans NFL betting odds. After opening the visitors as a touchdown favorite, oddsmakers and the market have bumped the spread up to double-digits ahead of this divisional matchup.

The following Colts vs Texans NFL betting preview will give you the current odds, betting trends and picks for the Week 13 matchup, along with a stream link to watch games all season long.

Colts vs Texans Week 13 NFL Betting Preview

NFL Regular Season — Week 13
Indianapolis Colts (6-6, 3-2 Away) vs. Houston Texans (2-9, 1-4 Home)
Date: Sunday, Dec. 5, 2021
Time: 1 p.m. EST
Venue: NRG Stadium — Houston, TX
Coverage: Click here for the stream

Indianapolis Colts Preview

The Colts dropped a seven-point game to the defending Super Bowl Champion Tampa Bay Buccaneers last Sunday, snapping a three-game winning streak. Indianapolis still impressed even in defeat, particularly on offense against the stout Bucs’ defense. It was strength on strength in the matchup between Jonathan Taylor and the Colts’ ground game against the Buccaneers’ run defense. Taylor still averaged over five yards per carry while quarterback Carson Wentz also had one of his most productive games on the season to date. If the Colts can pair a consistent aerial attack with their already nasty run game, they’ll be tough to stop offensively. 

One thing that Wentz certainly has in his favor is a greater variety of pass-catchers than what was available earlier in the year. In addition to T.Y. Hilton returning from his latest injury, tight end Jack Doyle is suddenly reemerging as a receiving threat. Where Indianapolis struggled in last week’s game was on defense. A unit that ranked first in adjusted efficiency against the run coming in allowed a big game to Leonard Fournette. That said, the Colts figure to have a much easier go of it in Sunday’s NFL betting matchup against the league’s worst scoring offense. 

Houston Texans Preview

After shocking the first place Tennessee Titans on the road, the Texans failed to string together back-to-back wins as they lost to the New York Jets last weekend. Houston took a 14-11 lead into the locker room at halftime last week but failed to score again over the final 30 minutes of play. It was a pathetic offensive display, something that Texans fans have had to endure plenty of this season. It was also very surprising given how awful the Jets defense is and the fact that Tyrod Taylor is back under center for Houston. That fact alone makes this second NFL betting matchup against the Colts different from the first. Taylor is clearly an upgrade over Davis Mills.

After cutting Phillip Lindsay, the Texans have resorted to a backfield tandem that features David Johnson and Rex Burkhead. However, the former was a nonparticipant at practice this week with an injury and illness. Given the stout Indianapolis run defense, Sunday’s game might be a big Burkhead usage situation regardless as the Texans will undoubtedly struggle on the ground. Other than Brandin Cooks, Taylor has very few reliable pass-catchers to throw to. Defensively, the Texans have actually jumped all the way up to eighth in the NFL in terms of adjusted efficiency. Their clear weakness is stopping the run, something that could spell major trouble against the Colts.

Credit: Morry Gash/AP Photo

Colts vs Texans Odds and Spread

NFL betting odds for Colts vs Texans are taken from BetMGM Sportsbook.

Moneyline: IND: (-550) | HOU: (+400)
Spread:
IND: -10 (-110) | HOU: +10 (-110)
Total:
44.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting
via Action Network: IND: (83%) | HOU: (17%)

Colts vs Texans NFL Betting Trends

  • Colts are 6-3 ATS in their last nine games. 
  • Seven of the Colts’ last eight road games have gone over the total.
  • Texans are just 3-6 ATS in their last nine games.
  • The total has gone under in five of the Texans’ last six games.
  • Colts are 6-1 ATS in their last seven head-to-head matchups against the Texans.

Signup for BetMGM Sportsbook today for a risk-free bet up to $1,000!


Colts vs Texans Stats

  • Indianapolis is averaging 28.3 points per game (PPG) this season (No. 4 in the NFL).
  • Indianapolis is surrendering 23.6 PPG this season (No. 20 in the NFL).
  • Houston is averaging 18.3 PPG this season (No. 26 in the NFL).
  • Houston is surrendering 14.9 PPG this season (No. 32 in the NFL).

Colts vs Texans Prediction

This Colts vs Texans NFL betting prediction uses NumberFire’s game projections. They give Indianapolis a 72.6% chance to win this Week 13 matchup.


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Henry’s passion for sports dates all the way back to childhood and has ultimately led to a full-fledged career as an analyst and content creator. After getting his start penning fantasy football articles, he forrayed into the betting side of the business in early 2019. His love for sports and statistics proved to be an ideal match with the dedicated research and strategy that handicapping requires. Henry currently specializes in betting analysis and picks for college football, college basketball and NASCAR. He counts the NFL, the WNBA, and NBA player props as additional leagues/markets of interest. Henry graduated from SUNY Buffalo in 2021 with a Communication Studies degree and a Psychology minor. A native of the Finger Lakes region in Upstate New York, he and his pup, Harold, have since relocated to Laramie, Wyoming. Thanks to his professional goals within the sports betting industry, there has been a whole lot of steam on the odds for a move to Las Vegas in 2023! Most of Henry’s free time is spent on outdoor adventures, playing chess, snowboarding, or reading a good book. He is also a competitive powerlifter and aspires to qualify for the USAPL Nationals meet within the next 2-3 years.

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