For the first time since October of 2018, the Indianapolis Colts and Buffalo Bills will go head-to-head on Saturday afternoon as part of NFL Wild Card Weekend. This article contains the NFL betting preview for the Colts vs Bills playoff matchup, including odds, spread, and NFL betting trends for the AFC Wild Card matchup.

Colts vs Bills Playoffs Preview | NFL Betting Preview

Colts vs Bills Playoffs Game Info

Indianapolis Colts (11-5, 5-3 Away) vs. Buffalo Bills (13-3, 7-1 Home)
Date: Saturday, Jan. 9, 2021
Time: 1:05 p.m. EST
Venue: Bills Stadium – Orchard Park, NY
Coverage: CBS

Credit: Tim Heitman/USA TODAY Sports

Colts vs Bills NFL Betting Odds

All NFL betting lines and odds are available on MyBookie Sportsbook

 Moneyline: IND: (+245) | BUF: (-305)
Spread: IND: +7 (-120) | BUF: -7 (+100)
Total: 51.5 – Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages: IND: (29%) | BUF: (71%)
Odds to Win Super Bowl LV: IND: (+5000) | BUF: (+650)

  • The Colts are 2-4 ATS in their last six games.
  • The Bills are 8-0 ATS in their last eight games.
  • 11 of the Bills’ 16 games this season went Over the total.
  • The Bills are 4-2 ATS in their last six head-to-head games against the Colts.
  • Home teams have been the outright winner in each of the last six head-to-head games between the Colts and Bills.
  • Under the total has hit in each of the last four and seven of the last eight head-to-head games between the Colts and Bills.

Colts vs Bills Stats

  • Indianapolis is averaging 28.2 points per game (PPG) this season (No. 9 in the NFL).
  • Indianapolis is surrendering 22.6 PPG this season (No. 10 in the NFL).
  • Buffalo is averaging 31.3 PPG this season (No. 2 in the NFL).
  • Buffalo is surrendering 23.4 PPG this season (No. 16 in the NFL).
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Henry’s passion for sports dates all the way back to childhood and has ultimately led to a full-fledged career as an analyst and content creator. After getting his start penning fantasy football articles, he forrayed into the betting side of the business in early 2019. His love for sports and statistics proved to be an ideal match with the dedicated research and strategy that handicapping requires. Henry currently specializes in betting analysis and picks for college football, college basketball and NASCAR. He counts the NFL, the WNBA, and NBA player props as additional leagues/markets of interest. Henry graduated from SUNY Buffalo in 2021 with a Communication Studies degree and a Psychology minor. A native of the Finger Lakes region in Upstate New York, he and his pup, Harold, have since relocated to Laramie, Wyoming. Thanks to his professional goals within the sports betting industry, there has been a whole lot of steam on the odds for a move to Las Vegas in 2023! Most of Henry’s free time is spent on outdoor adventures, playing chess, snowboarding, or reading a good book. He is also a competitive powerlifter and aspires to qualify for the USAPL Nationals meet within the next 2-3 years.

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