Bills vs Rams Prediction, NFL Betting Trends and Week 1 Picks

Week 1 of the 2022 NFL season kicks off with an exciting Thursday Night Football matchup between the Buffalo Bills and Los Angeles Rams. It’s a battle between this season’s Super Bowl favorite and last season’s Super Bowl champion. While past seasons’ TNF games have been forgettable, it’s clear this Bills vs Rams matchup is set to kick off this season with a BANG!

This NFL betting preview will discuss our Bills vs Rams prediction, NFL betting trends, odds and Week 1 NFL picks against the spread. But first, let’s take a look at this exciting NFL betting signup offer at BetOnline Sportsbook.

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Bills vs Rams Prediction | Week 1 NFL Picks Against the Spread

Thursday Night Football — Week 1
Buffalo Bills (0-0) vs. Los Angeles Rams (0-0)
Date: Thursday, Sept. 8, 2022
Time: 8:20 PM EST
Venue: SoFi Stadium — Inglewood, CA
Coverage: NBC

Bills vs Rams Prediction, NFL Betting Trends and Week 1 Picks Against the Spread — Credit: Gary A. Vasquez/USA TODAY Sports

Bills vs Rams Prediction, NFL Picks Against the Spread and Betting Odds

NFL betting odds for Bills vs Rams are taken from BetOnline Sportsbook.

Moneyline: BUF: (-130) | LAR: (+110)
Spread: BUF: -2 (-110) | LAR: +2 (-110)
Total: 52 — Over: (-110) | Under: (-110)
Public (Spread) Betting via Action Network: BUF: (71%) | LAR: (29%)

Bills vs Rams NFL Betting Trends

Bills were 10-7-2 in NFL picks against the spread (ATS) last season.
The OVER was 10-9 in Buffalo’s games last season.
Rams were 10-11 ATS last season.
The OVER was 10-10-1 in Rams games last season.

Bills vs Rams Stats

Buffalo averaged 29.8 points per game (PPG) last season (No. 3 in the NFL).
Buffalo surrendered 18.3 PPG last season (No. 1 in the NFL).
The Rams averaged 27.0 PPG last season (No. 6 in the NFL).
The Rams surrendered 21.3 PPG last season (T-No. 9 in the NFL).