Week 1 of the 2022 NFL season kicks off with an exciting Thursday Night Football matchup between the Buffalo Bills and Los Angeles Rams. It’s a battle between this season’s Super Bowl favorite and last season’s Super Bowl champion. While past seasons’ TNF games have been forgettable, it’s clear this Bills vs Rams matchup is set to kick off this season with a BANG!
This NFL betting preview will discuss our Bills vs Rams prediction, NFL betting trends, odds and Week 1 NFL picks against the spread. But first, let’s take a look at this exciting NFL betting signup offer at BetOnline Sportsbook.
NFL Week 1 BetOnline Sportsbook Promo: $2000 Bonus Today!
BetOnline Promo Free Money Offer: 100% Crypto Match Up to $1000!
This first NFL Week 1 BetOnline Sportsbook promo is for readers who like to bet using cryptocurrency. Along with many other deposit bonuses, BetOnline also has a first-time crypto deposit bonus, matching you dollar for dollar up to $1,000! Simply CLICK HERE, deposit your crypto with the BetOnline promo code CRYPTO100, and away you go!
BetOnline Promo Free Money Offer: 50% Deposit Match Up to $1000!
If you don’t have a crypto wallet and still want to take advantage of the BetOnline promo bonuses for NFL betting, don’t worry, there are plenty of other offers! For new BetOnline users, you can CLICK HERE to claim a 50% match on your very first deposit up to $1,000!
This BetOnline Sportsbook promo can be combined with the first one, meaning you can get $2,000 extra before even winning a bet!
Bills vs Rams Prediction | Week 1 NFL Picks Against the Spread
Thursday Night Football — Week 1
Buffalo Bills (0-0) vs. Los Angeles Rams (0-0)
Date: Thursday, Sept. 8, 2022
Time: 8:20 PM EST
Venue: SoFi Stadium — Inglewood, CA
Bills vs Rams Prediction, NFL Picks Against the Spread and Betting Odds
Moneyline: BUF: (-130) | LAR: (+110)
Spread: BUF: -2 (-110) | LAR: +2 (-110)
Total: 52 — Over: (-110) | Under: (-110)
Public (Spread) Betting via Action Network: BUF: (71%) | LAR: (29%)
Bills vs Rams NFL Betting Trends
- Bills were 10-7-2 in NFL picks against the spread (ATS) last season.
- The OVER was 10-9 in Buffalo’s games last season.
- Rams were 10-11 ATS last season.
- The OVER was 10-10-1 in Rams games last season.
Bills vs Rams Stats
- Buffalo averaged 29.8 points per game (PPG) last season (No. 3 in the NFL).
- Buffalo surrendered 18.3 PPG last season (No. 1 in the NFL).
- The Rams averaged 27.0 PPG last season (No. 6 in the NFL).
- The Rams surrendered 21.3 PPG last season (T-No. 9 in the NFL).
Bills vs Rams Prediction
This Week 1 NFL betting Bills vs Rams prediction uses NumberFire’s game projections. They give Buffalo a 55.1% chance to win this Week 1 matchup.
The FlurrySports experts also have their own Week 1 NFL Picks here.