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49ers vs Jaguars NFL Betting Odds, Trends, Stream and Picks for Week 11

Among the early afternoon NFL betting games this Sunday is a cross-conference matchup between the San Francisco 49ers and Jacksonville Jaguars. Although both teams enter this game with sub-.500 records, the path to a playoff berth is much clearer for the 49ers. San Francisco is also coming in on the heels of an impressive primetime victory. The NFL betting odds list the visitors as nearly a full touchdown favorite ahead of the sixth all-time 49ers vs Jaguars contest.

The following 49ers vs Jaguars NFL betting preview will give you the current odds, betting trends and picks for the Week 11 matchup, along with a stream link to watch games all season long.

49ers vs Jaguars Week 11 NFL Betting Preview

NFL Regular Season — Week 11
San Francisco 49ers (4-5, 3-1 Away) vs. Jacksonville Jaguars (2-7, 2-3 Home)
Date: Sunday, Nov. 21, 2021
Time: 1 p.m. EST
Venue: TIAA Bank Field — Jacksonville, FL
Coverage: Click here for the stream

San Francisco 49ers Preview

Just when everyone was ready to dismiss the 49ers, Kyle Shanahan’s bunch went out and put a beating on the division-rival Los Angeles Rams. The fact that they did it on the national viewing stage of Monday Night Football left plenty of NFL betting analysts in shock. Perhaps they shouldn’t have been. Injuries created turmoil for the Niners early in the season. With a healthy squad two weeks ago, they simply played a horrendous game against the shorthanded Arizona Cardinals. Last week’s game was a must-win for the 49ers to have any hopes of crawling back into the NFC West Division race. With their backs against the wall, a team that entered the year with a very respectable power rating exceeded updated expectations.

The biggest difference between the Cardinals game and this past Monday’s win over the Rams was the play of San Francisco’s defense. The much-maligned 49ers secondary forced two interceptions and held L.A. under 300 yards for the game. Running the ball remains as difficult as ever against the stacked defensive front. Speaking of running, Elijah Mitchell toted a season-high 27 carries on Monday night. He finished out the game despite suffering a broken finger. His status looks okay for Sunday’s NFL betting contest. If the rookie has to miss, veteran Jeff Wilson Jr. is back from his own stint on the PUP list and would shoulder the backfield load. Niners fans certainly had to be thrilled to see Jimmy Garoppolo hook up with both Deebo Samuel and George Kittle on touchdown strikes in last week’s win.

Jacksonville Jaguars Preview

After shocking the entire NFL betting world two weeks ago with a win over the Buffalo Bills, the Jaguars at least managed to play the AFC South rival Indianapolis Colts to a one-score game last Sunday. The best element of this rebuilding team is the run defense. The Jaguars enter Week 11 ranked 11th in rushing yards allowed per game (106.0) and seventh in adjusted defensive efficiency against the run. As such, it will be strength on strength in this matchup as Josh Allen and the rest of Jacksonville’s defensive front try to slow down the 49ers’ ground game. Doing so will be key to the underdogs having a shot at pulling off another surprise.

On offense, the onus is likely to fall on the arm of rookie QB Trevor Lawrence to make plays. Given how tough it is to run the ball on the Niners’ defense, one has to imagine that James Robinson’s production will be reduced. Unfortunately, Lawrence lacks a solid offensive line as well as ample pass-catchers. Tight end Dan Arnold has been the most reliable receiving option for the Jaguars in recent weeks. In reality, the team’s chances of springing another upset likely rest on the shoulders of the defense just as they did two weeks ago.

James Robinson NFL betting trends odds 49ers vs Jaguars prediction stream
Credit: Getty Images

49ers vs Jaguars Odds and Spread

NFL betting odds for 49ers vs Jaguars are taken from BetMGM Sportsbook.

Moneyline: SF: (-275) | JAC: (+230)
SF: -6.5 (-110) | JAC: +6.5 (-110)
45.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting
via Action Network: SF: (72%) | JAC: (28%)

49ers vs Jaguars NFL Betting Trends

  • 49ers are just 2-5 both SU and ATS in their last seven games.
  • Four of the 49ers’ last five games against AFC opponents have gone over the total.
  • Jaguars are 4-2 ATS in their last six games.
  • The total has gone under in seven of the Jaguars’ last eight games.
  • 49ers are 4-1 ATS in five previous head-to-head matchups against the Jaguars.

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49ers vs Jaguars Stats

  • San Francisco is averaging 24.0 points per game (PPG) this season (No. 16 in the NFL).
  • San Francisco is surrendering 23.6 PPG this season (T-No. 17 in the NFL).
  • Jacksonville is averaging 16.6 PPG this season (No. 31 in the NFL).
  • Jacksonville is surrendering 25.8 PPG this season (No. 27 in the NFL).

49ers vs Jaguars Prediction

This 49ers vs Jaguars NFL betting prediction uses NumberFire’s game projections. They give San Francisco a 68.1% chance to win this Week 11 matchup.

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