For the third time this season, the Seattle Seahawks will take on the San Francisco 49ers. However, this time the stakes are higher, as it’s a win-or-go-home NFL Playoffs matchup. Let’s take a look at the NFL Playoffs Wild Card Weekend betting preview for this game, including odds, trends, picks against the spread and a Seahawks vs 49ers prediction. But first, check out this incredible BetMGM Wild Card Weekend promo!

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Credit: Stan Szeto/USA TODAY Sports

Seahawks vs 49ers Prediction | NFL Playoffs Wild Card Weekend Preview

NFL Playoffs — Wild Card Weekend
Seattle Seahawks (9-8, 4-4 Away) vs. San Francisco 49ers (13-4, 8-1 Home)
Date: Saturday, January 14, 2022
Time: 4:30 p.m. EST
Venue: Levi’s Stadium — Santa Clara, CA
Coverage: FOX

Seahawks vs 49ers Odds & Spread

NFL betting odds for Seahawks vs 49ers are taken from BetMGM Sportsbook.

Moneyline: SEA: (+375) | SF: (-500)
Spread: SEA: +9.5 (-110) | SF: -9.5 (-110)
Total: 42 — Over: (-110) | Under: (-110)
Public (Spread) Betting via Action NetworkSEA: (41%) | SF: (59%)
Odds to Win Super Bowl LVII: SEA: (+10000) | SF: (+450)


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NFL Betting Trends for Seahawks vs 49ers

  • The Seahawks are 7-10 in NFL picks against the spread (ATS) this season.
  • The OVER is 8-9 in Seattle’s games this season.
  • The 49ers are 11-6 in NFL picks ATS this season.
  • The OVER is 9-8 in San Francisco’s games this season.

Seahawks vs 49ers Stats

  • Seattle averages 23.9 points per game (PPG) this season (No. 9 in the NFL).
  • Seattle surrenders 23.6 PPG this season (No. 25 in the NFL).
  • San Francisco averages 26.5 PPG this season (No. 6 in the NFL).
  • San Francisco surrenders 16.3 PPG this season (No. 1 in the NFL).

Seahawks vs 49ers Prediction

This NFL Playoffs betting Seahawks vs 49ers prediction uses NumberFire’s game projections. They give San Francisco a 74.7% chance to win this Wild Card Weekend matchup.

The FlurrySports experts also have their own NFL picks for the playoffs here.

NFL Playoffs Schedule | Super Wild Card Weekend

Saturday Games

Seattle Seahawks vs San Francisco 49ers

  • 4:35 pm ET, FOX

Los Angeles Chargers vs Jacksonville Jaguars

  • 8:15 pm ET, NBC

Sunday Games

Miami Dolphins vs Buffalo Bills

  • 1:05 pm ET, CBS

New York Giants vs Minnesota Vikings

  • 4:40 pm ET, FOX

Baltimore Ravens vs Cincinnati Bengals

  • 8:15 pm ET, NBC

Monday Games

Dallas Cowboys vs Tampa Bay Buccaneers

On Bye: Philadelphia Eagles, Kansas City Chiefs


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I am a simple Wisconsin man: I love beer and sports. I decided to create FlurrySports because I was sick of the politics and non-stories that the fat cat corporations put out. When you see football articles from me, just know that I combine my knowledge from playing, coaching, athletic training, and sports management/economic courses to give you a unique, but I feel well-rounded point of view. I am always down to talk about anything, so follow me on Twitter @FantasyFlurry if you decide you want more of me!

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