Seahawks vs 49ers Prediction, Odds and NFL Wild Card Weekend Picks

For the third time this season, the Seattle Seahawks will take on the San Francisco 49ers. However, this time the stakes are higher, as it’s a win-or-go-home NFL Playoffs matchup. Let’s take a look at the NFL Playoffs Wild Card Weekend betting preview for this game, including odds, trends, picks against the spread and a Seahawks vs 49ers prediction. But first, check out this incredible BetMGM Wild Card Weekend promo!

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Seahawks vs 49ers Prediction, Odds and NFL Wild Card Weekend Picks — Credit: Stan Szeto/USA TODAY Sports

Seahawks vs 49ers Prediction | NFL Playoffs Wild Card Weekend Preview

NFL Playoffs — Wild Card Weekend
Seattle Seahawks (9-8, 4-4 Away) vs. San Francisco 49ers (13-4, 8-1 Home)
Date: Saturday, January 14, 2022
Time: 4:30 p.m. EST
Venue: Levi’s Stadium — Santa Clara, CA
Coverage: FOX

Seahawks vs 49ers Odds & Spread

NFL betting odds for Seahawks vs 49ers are taken from BetMGM Sportsbook.

Moneyline: SEA: (+375) | SF: (-500)
Spread: SEA: +9.5 (-110) | SF: -9.5 (-110)
Total: 42 — Over: (-110) | Under: (-110)
Public (Spread) Betting via Action Network: SEA: (41%) | SF: (59%)
Odds to Win Super Bowl LVII: SEA: (+10000) | SF: (+450)

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NFL Betting Trends for Seahawks vs 49ers

The Seahawks are 7-10 in NFL picks against the spread (ATS) this season.
The OVER is 8-9 in Seattle’s games this season.
The 49ers are 11-6 in NFL picks ATS this season.
The OVER is 9-8 in San Francisco’s games this season.

Seahawks vs 49ers Stats

Seattle averages 23.9 points per game (PPG) this season (No. 9 in the NFL).
Seattle surrenders 23.6 PPG this season (No. 25 in the NFL).
San Francisco averages 26.5 PPG this season (No. 6 in the NFL).
San Francisco surrenders 16.3 PPG this season (No. 1 in the NFL).