The Green Bay Packers bounced back in Week 2 after being embarrassed in their first game. However, they must now head to the west coast, where they have struggled recently, to face the 2-0 San Francisco 49ers. The Packers’ offensive line is a trainwreck, but with the league’s best quarterback under center, will they be able to pull off the NFL betting upset?

The following Packers vs 49ers NFL betting preview will give you the current odds, betting trends and picks for the Week 3 matchup, along with a stream link to watch games all season long.

Packers vs 49ers SNF Week 3 NFL Betting Preview and Stream

NFL Regular Season — Week 3 Sunday Night Football
Green Bay Packers (1-1, 0-1 Away) vs. San Francisco 49ers (2-0, 0-0 Home)
Date: Sunday, September 26, 2021
Time: 8:25 p.m. EST
Venue: Levi’s Stadium – Santa Clara, CA
Coverage: Click here for the stream

Heading into this season, the Packers offensive line had some serious issues, as I said on Lombardi Sweep. Now, with Elgton Jenkins out tonight, Green Bay is in serious trouble, especially since they continue to be a team that panics whenever the running game doesn’t work. Defensively, they are also in trouble, as their defensive front will lose at the point of attack to the Niners’ offensive line. In order for the Packers to have a chance, Aaron Rodgers will need to be perfect and have complete freedom with the play-calls.

The 49ers have issues of their own, with injuries again hitting this team hard. Their backfield continues to lose running backs, though Trey Sermon should be able to play in this game. The offense simply looked off rhythm last week, and the best way to find it again is to run the football, which they should be able to do well. Defensively, the front seven is strong and the secondary is weak. In other words, they must get pressure in order to be effective.

Credit: Sports Illustrated

Packers vs 49ers Odds & Spread

NFL betting odds for Packers vs 49ers are taken from FanDuel Sportsbook.

Moneyline: GB: (+136) | SF: (-162)
Spread: GB: +3 (-110) | SF: -3 (-110)
Total: 50.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting via Action Network: GB: (35%) | SF: (65%)
Odds to Win Super Bowl LVI: GB: (+1500) | SF: (+1300)

Packers vs 49ers NFL Betting Trends

– Green Bay is 1-1 against the spread (ATS) this season.
– The game total is 1-1 for the Packers this season.
– San Francisco is 1-1 ATS this season.
– The game total is 1-1 for the 49ers this season.

Packers vs 49ers Stats

– Green Bay is averaging 19.0 points per game (PPG) this season (No. 26 in the NFL).
– Green Bay is surrendering 27.5 PPG this season (T-No. 23 in the NFL).
– San Francisco is averaging 29.0 PPG this season (T-No. 8 in the NFL).
– San Francisco is surrendering 22.0 PPG this season (T-No. 10 in the NFL).

Packers vs 49ers Prediction

The Packers vs 49ers NFL betting prediction uses the ESPN Football Power Index.

Packers: 38.2%
49ers: 61.5%
Tie: 0.3%


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I am a simple Wisconsin man: I love beer and sports. I decided to create FlurrySports because I was sick of the politics and non-stories that the fat cat corporations put out. When you see football articles from me, just know that I combine my knowledge from playing, coaching, athletic training, and sports management/economic courses to give you a unique, but I feel well-rounded point of view. I am always down to talk about anything, so follow me on Twitter @FantasyFlurry if you decide you want more of me!

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