The marquee late game on the Week 6 NFL betting slate pits the Dallas Cowboys against the New England Patriots. This cross-conference battle will showcase two teams with very different styles of play. Dallas will attempt to run their early-season winning streak to five straight while New England will aim to pick up their first home win of the year. The NFL betting odds have sided with the visitors ahead of this Cowboys vs Patriots showdown.

The following Cowboys vs Patriots NFL betting preview will give you the current odds, betting trends and picks for the Week 6 matchup, along with a stream link to watch games all season long.

Cowboys vs Patriots Week 6 NFL Betting Preview

NFL Regular Season — Week 6 Game
Dallas Cowboys (4-1, 1-1 Away) vs. New England Patriots (2-3, 0-3 Home)
Date: Sunday, Oct. 17, 2021
Time: 4:25 p.m. EST
Venue: Gillette Stadium — Foxborough, MA
Coverage: Click here for the stream

Dallas Cowboys Preview

After a lost season one year ago, the Cowboys have been one of the most impressive teams through five weeks in 2021. Dallas’ lone loss came in close fashion on opening night against the defending Super Bowl champs. Since then, the Cowboys have rattled off four straight wins. They rank second in scoring offense and are also the only team with a perfect NFL betting record ATS entering Week 6. Considering the vast array of playmakers on offense, it’s no surprise to see the Cowboys moving the ball at will. Dak Prescott’s comeback tour continued last Sunday with over 300 yards through the air and three touchdowns. Ezekiel Elliott has been a stat sheet-stuffer the past few weeks. He had another 110 yards rushing and two total touchdowns last week. Even backup RB Tony Pollard has been a weekly contributor for Dallas.

If there is one potential cause for concern on offense entering this week’s NFL betting matchup, it’s the health of top wideout Amari Cooper. He was banged up going into last week’s blowout of the New York Giants. While Cooper played through it and even scored a TD, he took another blow in the game when his ankle got rolled up on. Luckily, Prescott also has CeeDee Lamb and tight end Dalton Schultz at his disposal in the passing game. The Cowboys’ defense has been a great story thus far as well. Dan Quinn has completely transformed a unit that ranked near the bottom of the league one year ago. Dallas now sits sixth in adjusted defensive efficiency, per Football Outsiders.

New England Patriots Preview

The casual NFL betting fan might look at the Patriots’ last-second win last week over the lowly Houston Texans and dismiss this team as a quality opponent. However, it should be noted that New England was without four starting offensive linemen. The fact that Mac Jones was still able to lead them back to get the win, under those circumstances, is nothing to sneeze at. With a week of rest to get healthy, the Patriots undoubtedly made the move with their sights set on this Sunday’s showdown against a much tougher opponent. 

While New England should be much healthier upfront, running back Damien Harris is a true “questionable” ahead of Week 6. The fact that he was at least able to practice in a limited capacity on Thursday is encouraging. Expect rookie Rhamondre Stevenson to assume a larger role if Harris can’t go. While the Pats don’t have any bonafide superstars in terms of pass-catchers, they do have several capable weapons. Last week, it was Hunter Henry’s turn to lead the way. The tight end caught six balls for 75 yards and a score. As impressive as Dallas has looked offensively thus far, Bill Belichick will undoubtedly have a plan in place for his defense to take away the Cowboys’ best weapons.

Credit: Mitchell Leff / Getty Images

Cowboys vs Patriots Odds and Spread

NFL betting odds for Cowboys vs Patriots are taken from BetMGM Sportsbook.

Moneyline: DAL: (-185) | NE: (+155)
Spread:
DAL: -3.5 (-105) | NE: +3.5 (-115)
Total:
50.5 — Over: (-115) | Under: (-105)
Public (Spread) Betting
via Action Network: DAL: (81%) | NE: (19%)

Cowboys vs Patriots NFL Betting Trends

  • The Cowboys are 5-0 ATS and 1-4to the over this season.
  • The Patriots are 2-3 ATS and 1-4 to the over this season.
  • Cowboys are just 3-7 ATS in their last ten games played in October.
  • Patriots are just 3-6 both SU and ATS in their last nine games.
  • Patriots are 6-0 SU in their last six head-to-head matchups against the Cowboys.

Signup for BetMGM Sportsbook today for a risk-free bet up to $1,000!


Cowboys vs Patriots Stats

  • Dallas is averaging 34.0 PPG this season (No. 2 in the NFL).
  • Dallas is surrendering 23.4 PPG this season (T-No. 14 in the NFL).
  • New England is averaging 19.2 points per game (PPG) this season (No. 26 in the NFL).
  • New England is surrendering 18.4 PPG this season (No. 5 in the NFL).

Cowboys vs Patriots Prediction

The Cowboys vs Patriots NFL betting prediction uses the ESPN Football Power Index.

Cowboys: 56.0%
Patriots: 43.7%
Tie:
0.4%


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Henry’s passion for sports dates all the way back to childhood and has ultimately led to a full-fledged career as an analyst and content creator. After getting his start penning fantasy football articles, he forrayed into the betting side of the business in early 2019. His love for sports and statistics proved to be an ideal match with the dedicated research and strategy that handicapping requires. Henry currently specializes in betting analysis and picks for college football, college basketball and NASCAR. He counts the NFL, the WNBA, and NBA player props as additional leagues/markets of interest. Henry graduated from SUNY Buffalo in 2021 with a Communication Studies degree and a Psychology minor. A native of the Finger Lakes region in Upstate New York, he and his pup, Harold, have since relocated to Laramie, Wyoming. Thanks to his professional goals within the sports betting industry, there has been a whole lot of steam on the odds for a move to Las Vegas in 2023! Most of Henry’s free time is spent on outdoor adventures, playing chess, snowboarding, or reading a good book. He is also a competitive powerlifter and aspires to qualify for the USAPL Nationals meet within the next 2-3 years.

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