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Cardinals vs Panthers Prediction, NFL Betting Trends, Odds and Week 4 Picks Against the Spread

One of the most confusing and certainly the most publicly bet lines of NFL Week 4 comes to us from Cardinals vs Panthers, which saw Arizona open as 1.5-point underdogs. Both teams are 1-2 entering the matchup and the loser will likely fall out of any playoff contention. There has been so much money placed on the Arizona Cardinals that they are now favored by a point. In football, there is a famous saying that “public dogs always die,” but does that still hold true when they kick off the game as favorites?

This NFL betting preview will discuss our Cardinals vs Panthers prediction, NFL betting trends, odds and Week 4 NFL picks against the spread. But first, let’s take a look at this exciting NFL betting signup offer at BetOnline Sportsbook.

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Cardinals vs Panthers Prediction | Week 4 NFL Picks Against the Spread

Arizona Cardinals (1-2, 1-0 Away) vs. Carolina Panthers (1-2, 1-1 Home)
Date: Sunday, Oct. 2, 2022
Time: 4:05 PM EST
Venue: Bank of America Stadium — Charlotte, NC
Coverage: FOX

QB Comparison: Arizona – Kyler Murray (90/141, 784 Yds, 3 TD, 1 INT) | Carolina – Baker Mayfield (42/81, 550 Yds, 3 TD, 1 INT)

The Arizona Cardinals have had an atypical start to their season, as they are just 1-2 when we have all grown accustomed to them being early-season world-beaters. Something is strange about the Cardinals getting points this week. We may end up looking like the biggest suckers on the planet, but the FlurrySports gambling minds as a whole are betting on the Cardinals this week. They have underperformed as an offensive unit this season, but have shown the ability to score points in bursts and in desperation situations. These are traits the Carolina Panthers do not possess.

Instead, the Panthers are once again going to have to rely on their defense. All the Panthers try and do is hold their opponents to field goals. Unfortunately for them, the Cardinals have one of the biggest legs in NFL history on their sideline. Points are going to be scored in this game, and we like the over as the Panthers will likely fall behind early and be forced to score in order to keep up.

Reports out of Carolina are that the locker room has lost respect for and belief in head coach Matt Rhule, who is the odds-on favorite to be the first coach fired. One of these teams will end up 1-3 following the conclusion of this game. We are convinced it will not be Arizona.

Cardinals vs Panthers Prediction, NFL Betting Trends, Odds and Week 4 Picks Against the Spread
Credit: Todd Olszewski/Getty Images

Cardinals vs Panthers Prediction, NFL Picks Against the Spread and Betting Odds

NFL betting odds for Cardinals vs Panthers are taken from BetOnline Sportsbook.

Moneyline: ARI: (NA) | CAR: (NA)
Spread: 
ARI: -1 (even) | CAR: +1 (-120)
Total: 
43.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting 
via Action NetworkARI: (82%) | CAR: (18%)


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NFL Betting Trends for Cardinals vs Panthers

  • The Cardinals are 1-2 in NFL picks against the spread (ATS) this season.
  • The OVER is 1-1-1 in Arizona’s games this season.
  • The Panthers are 1-2 in NFL picks ATS this season.
  • The OVER is 1-2 in Carolina’s games this season.

Cardinals vs Panthers Stats

  • Arizona averages 20.7 points per game (PPG) this season (T-No. 13 in the NFL).
  • Arizona surrenders 29 PPG this season (No. 31 in the NFL).
  • Carolina averages 20.7 PPG this season (T-No. 13 in the NFL).
  • Carolina surrenders 19.7 PPG this season (T-No. 12 in the NFL).

Cardinals vs Panthers Prediction

This Week 4 NFL betting Cardinals vs Panthers prediction uses NumberFire’s game projections. They give Arizona a 62% chance to win this Week 4 matchup.

The FlurrySports experts also have their own Week 4 NFL Picks here.


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