After both NFC South teams scored a victory last week, the Tampa Bay Buccaneers and New Orleans Saints will face off in NFL Week 2. This NFL betting preview will discuss our Buccaneers vs Saints prediction, NFL betting trends, odds and Week 2 NFL picks against the spread. But first, let’s take a look at this exciting NFL betting signup offer at BetOnline Sportsbook.

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Buccaneers vs Saints Prediction | Week 2 NFL Picks Against the Spread

NFL Regular Season — Week 2
Tampa Bay Buccaneers (1-0, 1-0 Away) vs. New Orleans Saints (1-0, 0-0 Home)
Date: Sunday, Sept. 18, 2022
Time: 1 PM EST
Venue: Caesars Superdome — New Orleans, LA
Coverage: FOX

Credit: Derick E. Hingle/USA TODAY Sports

Buccaneers vs Saints Prediction, NFL Picks Against the Spread and Betting Odds

NFL betting odds for Buccaneers vs Saints are taken from BetOnline Sportsbook.

Moneyline: TB: (-145) | NO: (+125)
Spread: 
TB: -2.5 (-110) | NO: +2.5 (-110)
Total: 
44.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting 
via Action NetworkTB: (50%) | NO: (50%)

Buccaneers vs Saints NFL Betting Trends

  • The Buccaneers are 1-0 in NFL picks against the spread (ATS) this season.
  • The OVER is 0-1 in Tampa Bay’s games this season.
  • The Saints are 0-1 in NFL picks ATS this season.
  • The OVER is 1-0 in New Orleans’ games this season.

Buccaneers vs Saints Stats

  • Tampa Bay averages 19 points per game (PPG) this season (T-No. 22 in the NFL).
  • Tampa Bay surrenders 3 PPG this season (No. 1 in the NFL).
  • New Orleans averages 27 PPG this season (No. 6 in the NFL).
  • New Orleans surrenders 26 PPG this season (T-No. 25 in the NFL).

Buccaneers vs Saints Prediction

This Week 2 NFL betting Buccaneers vs Saints prediction uses NumberFire’s game projections. They give New Orleans a 50.8% chance to win this Week 2 matchup.

The FlurrySports experts also have their own Week 2 NFL Picks here.


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I am a simple Wisconsin man: I love beer and sports. I decided to create FlurrySports because I was sick of the politics and non-stories that the fat cat corporations put out. When you see football articles from me, just know that I combine my knowledge from playing, coaching, athletic training, and sports management/economic courses to give you a unique, but I feel well-rounded point of view. I am always down to talk about anything, so follow me on Twitter @FantasyFlurry if you decide you want more of me!

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