FlurrySports takes a look at the three best NFL DFS stacks to pick for your Week 10 lineups on DraftKings.
Stacking is a common strategy in all daily fantasy sports and is a simple concept. If a team performs well, correlated players from that same team will score a lot of points. This is enhanced even more when talking about pass catchers and quarterbacks or, if you like to be really daring, pairing running backs with defenses in games that look like they could be lopsided.
All prices and budgets for NFL DFS stacks in this article assume DraftKings pricing. Here are the three best fantasy football stacks to consider for your Week 10 NFL DFS lineups, with a bonus at the end.
Best NFL DFS Stacks For DraftKings Week 10
Mac Jones ($5000) + Christian McCaffrey ($9000) + George Kittle ($4500) total cost – $18,500 (37% of total budget)
The San Francisco 49ers get the Rams this week, a team they beat already without George Kittle or Jauan Jennings. If you can remember, it was the Kendrick Bourne show, as the former Patriots WR went for 10/142 while CMC racked up 8/82/1 to go along with 57 rushing yards. San Fran tight ends Jake Tonges and Luke Farrell combined for 8/49/1 as well.
This game has massive divisional and playoff implications for both teams, so big days for the stars on both sides should be expected. Mac Jones has been serviceable for fantasy in relief of Brock Purdy this year, CMC has been probably the best value in your draft in the back end of the first round, and Kittle is a danger to score 25 anytime he’s healthy. I wouldn’t kill you for swapping out Kittle for Jennings at cost in an effort to get off Kittle, who will likely draw higher ownership with no Tyler Warren, Jake Ferguson, Tyler Kraft or Dallas Goedert on this slate.

Matthew Stafford ($6500) + Puka Nacua ($8700) + Davante Adams ($7700) total cost – $22,900 (45.8% of budget)
If you feel really confident about this game and the players in it, I could see playing this stack in lieu of the previous one. Be wary of ownership in tournaments, as this game will likely be the most popular for stacks on both sides, especially considering the Rams’ narrow target share between Puka Nacua and Davante Adams. Puka and Adams combined for 23 of Stafford’s 47 attempts in the previous meeting, with Puka turning in a WR5 performance and Adams being a touchdown away from likely doing the same the last time these teams met.
Kyren Williams is likely to factor into this game, but since he does not get a lot of work in the passing game (more than four targets once this year), I am not considering him in the stack. It was against the 49ers, however, that Kyren had that outlier 10-target day, but that is probably more of a product of Stafford throwing 47 times during that game. Unless an injury occurs, stacking either side of this NFC West tilt is a solid play. In an effort to get different against the field, I would not mind going Kyren and CMC from this game only in an effort to be contrarian in tournaments.
Baker Mayfield ($6200) + Emeka Egbuka ($7000) + Tez Johnson ($4500) total cost – $17,700 (35.4% of budget)
The “budget stack,” if you will, this week. Baker Mayfield and the Bucs host New England at home. Drake Maye has been unbelievable this season and has been getting MVP buzz in some circles, like Baker was earlier in the season. This game has a somewhat modest total, at 48, but has shootout potential due to the men under center on both sides.
With no Mike Evans or Chris Godwin, the Bucs’ passing attack should be heavily condensed around Emeka Egbuka and Tez Johnson; the former had begun to cool off from his blistering pace early in the year, but was also nursing injuries. Now that he’s had a week of rest to get right, I wouldn’t be shocked to see Egbuka get back to those performances we saw in the first five weeks. The Patriots are strong against the run defensively, also leaning into what should be a positive overall situation for the Tampa Bay passing offense on Sunday.
Playing the opposite side of this game is tricky because, much like Josh Allen, who do you stack Drake Maye with? If I am playing Maye, it is likely naked or with Hunter Henry only because projecting who has the day for the Pats in the pass game has been inconsistent.
Bonus mini-stack: Quinshon Judkins ($6500) + Browns D/ST ($2900)
Let’s have a little fun, shall we?
We’ve seen this movie before from Justin Fields; if there was ever a Jekyll and Hyde fantasy player, it is him. If he’s playing a bad defense, he nukes; if he’s not playing a team that would be better off finding defense in the USFL, he looks like Kendall Hinton. The Browns’ defense is top-six against fantasy QBs and the second-best team against fantasy RBs, while the Jets have been marginally bad against fantasy rushers.
It’s no secret that the Browns want to pound the rock, play defense and dump it off to Harold Fannin Jr. seven times a game.
This game has the lowest total of the week, at 37, suggesting that points will be at a premium. I wouldn’t be shocked to see a low-scoring slog where Judkins falls in the end zone twice and Fields throws two or three interceptions.
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