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49ers vs Eagles NFL Betting Odds, Trends, Stream and Picks for Week 2

Both the San Francisco 49ers and the Philadelphia Eagles dominated their matchups against terrible opponents in Week 1. However, San Francisco left the game with injuries, giving fans terrible flashbacks to last season. Eagles fans know exactly how that feels, as their team has been decimated for the past several years. However, being the more healthy team at home, will that be enough for them in this NFL betting matchup?

The following 49ers vs Eagles NFL betting preview will give you the current odds, betting trends and picks for the Week 2 matchup, along with a stream link to watch games all season long.

49ers vs Eagles Week 2 NFL Betting Preview and Stream

NFL Regular Season — Week 2 Game
San Francisco 49ers (1-0, 1-0 Away) vs. Philadelphia Eagles (1-0, 0-0 Home)
Date: Sunday, September 19, 2021
Time: 1:00 p.m. EST
Venue: Lincoln Financial Field — Philadelphia, PA
Coverage: Click here for the stream

The 49ers had a dominating Week 1 win over the Lions, but they left the game with a couple of injuries. Raheem Mostert left early will miss the rest of the season with a knee injury. Starting cornerback Jason Verrett was also lost for the season to an ACL tear. However, they did look good in the game. Elijah Mitchell filled in nicely running the football, while the passing game was incredibly efficient. Defensively, they were able to total three sacks, but they must contain a mobile quarterback this week.

Nobody expected the Eagles to look that good in Week 1, defeating the Falcons 32-6 on the road. While Atlanta is not a good team, Jalen Hurts impressed many, completing 27/35 passes for 264 yards and three touchdowns. Philadelphia also averaged 5.6 yards per carry and, more importantly, the defense kept the Falcons out of the end zone. We will see how they hold up against a team that can run against anyone.

49ers vs eagles nfl betting picks trends odds
Credit: Stacy Revere/Getty Images

49ers vs Eagles Odds and Spread

NFL betting odds for 49ers vs Eagles are taken from FanDuel Sportsbook.

Moneyline: SF: (-174) | PHI: (+146)
Spread: SF: -3 (-110) | PHI: +3 (-110)
Total: 49.5 — Over: (-106) | Under: (-114)
Public (Spread) Betting Percentages via oddsFire: SF: (25%) | PHI: (75%)
Odds to Win Super Bowl LVI: SF: (+1300) | PHI: (+7000)

49ers vs Eagles NFL Betting Trends

– San Francisco is 0-1 against the spread (ATS) this season.
– The total hit the over in the 49ers’ first game this season.
– Philadelphia is 1-0 ATS this season.
– The total hit the Under in the Eagles’ first game this season.

49ers vs Eagles Stats

– San Francisco is averaging 41.0 points per game (PPG) this season (No. 1 in the NFL).
– San Francisco is surrendering 33.0 PPG this season (T-No. 25 in the NFL).
– Philadelphia is averaging 32.0 PPG this season (No. 9 in the NFL).
– Philadelphia is surrendering 6.0 PPG this season (No. 2 in the NFL).

49ers vs Eagles Prediction

The 49ers vs Eagles NFL betting prediction uses the NumberFire Picks tool.

49ers -3.5: 53.6%
Eagles +3.5: 46.4%


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