Thursday Night Football for Week 16 features two teams fighting to make the playoffs. While the San Francisco 49ers are surging and claiming one of the wild card spots as their own, the Tennessee Titans are limping down the homestretch and desperately trying to hold onto their playoff spot. Needless to say, this is an important game for both teams, making it intriguing from an NFL betting perspective.
The following 49ers vs Titans NFL betting preview will give you the current odds, betting trends and picks for the Week 16 matchup, along with a stream link to watch games all season long.
49ers vs Titans TNF Week 16 NFL Betting Preview and Stream
NFL Regular Season — Week 16 Thursday Night Football
San Francisco 49ers (8-6, 5-2 Away) vs. Tennessee Titans (9-5, 5-2 Home)
Date: Thursday, December 23, 2021
Time: 8:20 p.m. EST
Venue: Nissan Stadium — Nashville, TN
Coverage: Click here for the stream
The 49ers are rolling, winning five of their past six games. This has them currently in the sixth seed of the NFC, behind two other teams in their own division. With another tough game against the Rams the final game of the season, the 49ers would love to win their next two games and hopefully lock up a playoff spot by then. The team is getting healthier, George Kittle is looking unstoppable and the defense is making a lot of noise. They have averaged four sacks over per game over their last three.
The Titans have a one-game lead in their division over the Indianapolis Colts, but they are stumbling down the homestretch of the season. They have lost three of their past four games, with their only win coming against Jacksonville. The Titans have a chance to get receiver A.J. Brown back this week, and Julio Jones seems like he may play through yet another hamstring injury. However, this team still looks out of sync without Derrick Henry running the rock 20+ times. The defense is also playing better than their talent level states, but the secondary can be exposed by competent teams, as the 49ers are.
49ers vs Titans Odds & Spread
NFL betting odds for 49ers vs Titans are taken from BetMGM Sportsbook.
Moneyline: SF: (-184) | TEN: (+154)
Spread: SF: -3.5 (-110) | TEN: +3.5 (-110)
Total: 44.5 — Over: (-110) | Under: (-110)
Public (Spread) Betting via Action Network: SF: (29%) | TEN: (71%)
Odds to Win Super Bowl LVI: SF: (+2800) | TEN: (+2600)
49ers vs Titans NFL Betting Trends
– San Francisco is 7-7 against the spread (ATS) this season.
– The Over is 7-7 for the 49ers this season.
– Tennessee is 8-6 ATS this season.
– The Over is 7-7 for the Titans this season.
49ers vs Titans Stats
– San Francisco is averaging 25.7 points per game (PPG) this season (No. 13 in the NFL).
– San Francisco is surrendering 22.4 PPG this season (T-No. 18 in the NFL).
– Tennessee is averaging 24.1 PPG this season (No. 15 in the NFL).
– Tennessee is surrendering 22.1 PPG this season (No. 16 in the NFL).
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49ers vs Titans Prediction
The 49ers vs Titans NFL betting prediction uses the ESPN Football Power Index.
49ers: 51.0%
Titans: 48.6%
Tie: 0.4%
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